Pt(iv) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

Alvaro Lopez-Sanchez and Helene C. Bertrand

Inorg. Chem. Front., 2024, 11, 1639
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Platinum(IV) Prodrugs Incorporating an Indole-Based Derivative, 5-Benzyloxyindole-3-Acetic Acid in the Axial Position Exhibit Prominent Anticancer Activity

Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott and Janice R. Aldrich-Wright

IJMS, 2024, 25, 2181
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Ab Initio Investigations of Optoelectronic and Transport Behavior of Mn and Eu‐Doped ZnxAxSiGeN4 Using GGA + U Functional: A Study for Optoelectronic Devices

Muhammad Irfan, M. M. Moharam, Ebraheem Abdu Musad Saleh, Ahmad M. Saeedi, Gideon F. B. Solre, Waseem Abbas, Adel A. El-Zahhar, Gamil A. A. M. Al-Hazmi, Sayed M. Eldin and Sana Ullah Asif

J Inorg Organomet Polym, 2024, 34, 3384
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Pt(IV) Complexes as Anticancer Drugs and Their Relationship with Oxidative Stress

Vlad Iova, Radu Ciprian Tincu, Ioana Scrobota and Mihail Silviu Tudosie

Biomedicines, 2025, 13, 981
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Recent advances in antitumor Pt(IV) complexes: Dual targeting and chemoimmunotherapy

Daniil Spector, Anastasia Zharova, Vladislav Bykusov, Georgy Karetnikov, Elena Beloglazkina and Olga Krasnovskaya

Coordination Chemistry Reviews, 2025, 541, 216808
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Synthesis, Characterization, ADME, Molecular Docking, In Silico Structural and Mechanistic Studies and Biological Activities of Pt(IV) Complexes Based on Diamine Derivatives

Sattar R. Majeed, Mina A. Amin, Hasan Yavuz Goren, Burcu Dedeoglu, Fawzy A. Attaby and Ahmed A. Soliman

Applied Organom Chemis, 2025, 39
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Drugs from drugs: New chemical insights into a mature concept

Eloy Lozano Baró, Federica Catti, Carolina Estarellas, Ouldouz Ghashghaei and Rodolfo Lavilla

Drug Discovery Today, 2024, 29, 104212
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Protonation of Pt(IV) Anticancer Complexes Assayed by Vibrational Ion Spectroscopy

Davide Corinti, Elisabetta Gabano, Barbara Chiavarino, Maria Elisa Crestoni, Domenico Osella and Simonetta Fornarini

ChemPlusChem, 2025, 90
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A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin and Hélène C. Bertrand

Adv Healthcare Materials, 2025, 14
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Red‐Light Photocatalytic Activation of Pt(IV) Anticancer Prodrugs Using Methylene Blue

Ana C. Carrasco, Greta Bajetto, Stefano Scoditti, German E. Pieslinger, Francesco Gambino, Marco De Andrea, Emilia Sicilia, Virginia Martínez‐Martínez, Valentina Dell'Oste and Luca Salassa

ChemCatChem, 2025, 17
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Current Status of Novel Multifunctional Targeted Pt(IV) Compounds and Their Reductive Release Properties

Lingwen Xu, Xiangyu Kong, Xinzhi Li, Bin Zhang, Yuxiao Deng, Jinhu Wang, Chonggang Duan, Daizhou Zhang and Wentao Liu

Molecules, 2024, 29, 746
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Machine Learning-Based Prediction of Reduction Potentials for PtIV Complexes

V. Vigna, T. F. G. G. Cova, S. C. C. Nunes, A. A. C. C. Pais and E. Sicilia

J. Chem. Inf. Model., 2024, 64, 3733
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Photoactivatable Cisplatin-Combretastatin-BODIPY Pt(IV) Prodrug for Dual-Action Light-Controlled Chemotherapy

Daniil V. Spector, Georgy Karetnikov, Anna Bubley, Roman A. Akasov, Yulia A. Isaeva, Tatiana V. Egorova, Alexander G. Martynov, Dmitry Bunin, Dmitry A. Skvortsov, Daria Ipatova, Alexander S. Erofeev, Petr V. Gorelkin, Vugara Mamed-Nabizade, Vasilii S. Kolmogorov, Alexander N. Vaneev, Igor A. Rodin, Mikhail F. Vokuev, Yuri K. Grishin, Vitaly A. Roznyatovsky, Vita N. Nikitina, Elena K. Beloglazkina and Olga O. Krasnovskaya

ACS Pharmacol. Transl. Sci., 2025, 8, 3296
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Pt(IV) prodrugs containing aliphatic amine in axial ligands with anticancer properties: Advanced synthesis, solubility, reduction, cytotoxicity, cell mechanism, DNA interaction, molecular docking, and molecular dynamics simulations

Maryam Sadeghi, Mahboube Eslami Moghadam, Morteza Rezaeisadat, Abdul Wahid Mesbah and Meissam Noroozifar

International Journal of Biological Macromolecules, 2025, 330, 148013
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Reduction of anticancer prodrugs cis-diamminetetrachloroplatinum(IV) and ormaplatin by a large series of thiols: Phenomenal structure-reactivity correlations

Yanqing Xia, Hongwu Tian, Zili Yin, Chen Jiang, Zhong Liu, Han Zhang, Weixing Zhang, Guimin Zhang, Chunli Liu and Tiesheng Shi

Journal of Molecular Structure, 2025, 1329, 141394
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Novel Cytotoxic Pt(IV) Compounds with Improved Safety Profiles

Anastasia A. Antonets, Ksenia M. Voroshilkina, Ilya A. Shutkov, Dmitrii M. Mazur, Tatiana P. Serkova, Elena F. Shevtsova, Dmitrii S. Yakovlev, Mariya S. Pshenichnikova, Umida M. Ibragimova, Roman A. Litvinov, Alexander A. Spasov, Elena R. Milaeva and Alexey A. Nazarov

IJMS, 2026, 27, 1750
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“Non-Classical” Platinum Complexes: A Concise Review

Adriana Bakalova, Nina Ruseva and Emiliya Cherneva

IJMS, 2025, 26, 6270
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Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells

Claudio Casali, Ludovica Gaiaschi, Enrico Pelloni, Federica Gola, Margherita Cavallo, Gloria Milanesi, Mauro Ravera, Marco Biggiogera, Fabrizio De Luca and Maria Grazia Bottone

Front. Cell Dev. Biol., 2025, 13
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