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Metal-based strategies for the fight against COVID-19

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Oxide anchored multi-charged metal complexes with binary nanoparticles for stable and efficient anti-bacterial coatings on cotton fabrics

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Sulfonamide-containing copper(ii) complexes: new insights on biophysical interactions and antibacterial activities

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Copper(ii) and silver(i) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex

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What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

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Metallodrugs are unique: opportunities and challenges of discovery and development

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Evaluation of cyrhetrenyl and ferrocenyl precursors as 5-lipoxygenase inhibitors – biological and computational studies

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Metal compounds as antimicrobial agents: ‘smart’ approaches for discovering new effective treatments

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Metal complexes as a promising source for new antibiotics

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Metallotherapeutics development in the age of iron-clad bacteria

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Metallomics, 2020, 12, 1863
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Medicinal inorganic chemistry – challenges, opportunities and guidelines to develop the next generation of radioactive, photoactivated and active site inhibiting metal-based medicines

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Silver(i) complexes containing antifungal azoles: significant improvement of the anti-Candida potential of the azole drug after its coordination to the silver(i) ion

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Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(v) dioxo complexes

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Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes

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Chem. Sci., 2023, 14, 711
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Copper(ii) complexes with terpene derivatives of ethylenediamine: synthesis, and antibacterial, antifungal and antioxidant activity

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Inert cationic iridium(iii) complexes with phenanthroline-based ligands: application in antimicrobial inactivation of multidrug-resistant bacterial strains

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Accessing spiropiperidines from dihydropyridones through tandem triflation–allylation and ring-closing metathesis (RCM)

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Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy

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19F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes

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Chem. Commun., 2021, 57, 4934
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Clinically used antifungal azoles as ligands for gold(iii) complexes: the influence of the Au(iii) ion on the antimicrobial activity of the complex

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Synthesis, structure diversity, and antimicrobial studies of Ag(i) complexes with quinoline-type ligands

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CrystEngComm, 2023, 25, 3922
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Metal complexes for therapeutic applications

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Trends in Chemistry, 2021, 3, 523
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Bridging informatics and medicinal inorganic chemistry: Toward a database of metallodrugs and metallodrug candidates

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Drug Discovery Today, 2022, 27, 1420
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Current Challenges and Opportunities in Designing Protein–Protein Interaction Targeted Drugs

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AABC, 2020, Volume 13, 11
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Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

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Beilstein J. Nanotechnol., 2025, 16, 1350
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Construction of the Akuammiline Alkaloid Core Structure via Stereoselective E-Ring Formation

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J. Org. Chem., 2024, 89, 10388
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A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis

Martin R. Gill, Paul J. Jarman, Vanessa Hearnden, Simon D Fairbanks, Marcella Bassetto, Hannes Maib, John Palmer, Kathryn R. Ayscough, Jim A. Thomas and Carl Smythe

Angew Chem Int Ed, 2022, 61
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Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction

Alan E. Bilsland, Kirsten McAulay, Ryan West, Angelo Pugliese and Justin Bower

J. Chem. Inf. Model., 2021, 61, 2547
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Ruthenium(II) Polypyridyl Complexes and Metronidazole Derivatives: A Powerful Combination in the Design of Photoresponsive Antibacterial Agents Effective under Hypoxic Conditions

Gina Elena Giacomazzo, Luca Conti, Camilla Fagorzi, Marco Pagliai, Claudia Andreini, Annalisa Guerri, Brunella Perito, Alessio Mengoni, Barbara Valtancoli and Claudia Giorgi

Inorg. Chem., 2023, 62, 7716
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Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry

Eduardo H. S. Sousa, Izaura C. N. Diógenes, Luiz G. F. Lopes and José J. G. Moura

J Biol Inorg Chem, 2020, 25, 685
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Rhenium Complexes as Antimicrobial Agents

Fabio Zobi, Gozde Demirci and Marija Rasic

Helvetica Chimica Acta, 2026
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In the search for new gold metalloantibiotics: In vitro evaluation of Au(III) (C^S)-cyclometallated complexes

Paula Pérez-Ramos, Yaiza Gabasa, Enmanuel Cornielle, Humberto Rodríguez-Solla, Sara M. Soto and Raquel G. Soengas

Journal of Inorganic Biochemistry, 2025, 262, 112735
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Nontoxic Cobalt(III) Schiff Base Complexes with Broad‐Spectrum Antifungal Activity

Angelo Frei, A. Paden King, Gabrielle J. Lowe, Amy K. Cain, Francesca L. Short, Hue Dinh, Alysha G. Elliott, Johannes Zuegg, Justin J. Wilson and Mark A. T. Blaskovich

Chemistry A European J, 2021, 27, 2021
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Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration

Mziyanda Mbaba, Taryn M. Golding, Reinner O. Omondi, Roxanne Mohunlal, Timothy J. Egan, Janette Reader, Lyn-Marie Birkholtz and Gregory S. Smith

European Journal of Medicinal Chemistry, 2024, 271, 116429
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Advanced and Biomedical Applications of Schiff-Base Ligands and Their Metal Complexes: A Review

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Crystals, 2022, 12, 1436
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Playing with Structural Parameters in the Design of Ruthenium(II)–p-Cymene Complexes as Potential Antibacterial Agents

Gina Elena Giacomazzo, Valentina Ceccherini, Valentina Vitali, Luca Conti, Francesca Vaccaro, Francesca Coscione, Elena Perrin, Marco Fondi, Lara Massai, Claudia Giorgi and Luigi Messori

Inorg. Chem., 2025, 64, 23414
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New fac-[Re(CO)3(OO)(L)] and [Re(CO)2(OO)(L)2] Complexes Bearing Two Natural Food Additives, Maltol and Kojic Acid, as OO Ligands

Angeliki Panagiotopoulou, Patricia Kyprianidou, Charalampos Tsoukalas, Vassilis Psycharis, Catherine P. Raptopoulou, Ioannis Pirmettis, Minas S. Papadopoulos and Maria Pelecanou

Crystals, 2024, 14, 515
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Synthesis, biological and medicinal impacts of metallodrugs: A study

Emranul Kabir, M.R.O. Khan Noyon and Md. Amjad Hossain

Results in Chemistry, 2023, 5, 100935
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Anticancer activity and DNA interaction of bis(pyridyl)allene-derived metal complexes

Hanna K. Maliszewska, Mahmoud A. S. Abdelhamid, María J. Marín, Zoë A. E. Waller and María Paz Muñoz

Pure and Applied Chemistry, 2023, 95, 377
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An Experimental and Molecular modelling Study of Ruthenium(II) Polypyridyl Complexes with a Thiazole-Imidazo-Phenanthroline Ligand and their DNA Affinity

Navaneetha Nambigari, Sravani Gudikandula and Satyanarayana Sirasani

J Fluoresc, 2026
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Targeting super bugs: metal complexes as emerging anti-microbial and anti-biofilm agents

Tarunkarthick Subramani and Suneetha Vuppu

Arch Microbiol, 2026, 208
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Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry

Julia Helena Bormio Nunes, Douglas Hideki Nakahata, Pedro Paulo Corbi and Raphael Enoque Ferraz de Paiva

Coordination Chemistry Reviews, 2023, 490, 215228
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Late transition metal complexes of ferrocene‐containing nitrogen ligands: Coordination chemistry, electron transfer properties, and tumor cell viability

Silvio Jakopec, Natalija Pantalon Juraj, Dijana Jadreško, Robert Vianello, Anamaria Brozovic, Vanja Tadić, Lea Milić, Berislav Perić, Silvana Raić‐Malić and Srećko I. Kirin

Applied Organom Chemis, 2024, 38
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Palladium complexes with terpene derivatives of ethylenediamine and benzylamine: Synthesis and study of antitumor properties

O.A. Zalevskaya, Y.A. Gur'eva, A.V. Kutchin, Yu.R. Aleksandrova, E.Yu. Yandulova, N.S. Nikolaeva and M.E. Neganova

Inorganica Chimica Acta, 2021, 527, 120593
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Integrative Metallomics Studies of Toxic Metal(loid) Substances at the Blood Plasma–Red Blood Cell–Organ/Tumor Nexus

Maryam Doroudian and Jürgen Gailer

Inorganics, 2022, 10, 200
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Synthesis and potential vasorelaxant effect of a novel ruthenium-based nitro complex

Joselito de Oliveira Neto, Márcia Machado Marinho, João Alison de Moraes Silveira, Danilo Galvão Rocha, Natália Cavalcante Barbosa Lima, Florêncio Sousa Gouveia Júnior, Luiz Gonzaga de França Lopes, Eduardo Henrique Silva de Sousa, Alice Maria Costa Martins, Aline Diogo Marinho, Roberta Jeane Bezerra Jorge and Helena Serra Azul Monteiro

Journal of Inorganic Biochemistry, 2022, 228, 111666
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Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion

Małgorzata Gawrońska, Mateusz Kowalik, Joanna Duch, Katarzyna Kazimierczuk and Mariusz Makowski

Polyhedron, 2022, 221, 115865
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High Inhibition for a CoII Tetrazole Bi‐pyrazole Dinuclear Complex against Fusarium Oxysporum f. sp. Albedinis

Yousra Bahjou, Smaail Radi, Mohamed El Massaoudi, Youssef Draoui, Nayarassery N. Adarsh, Haralampos N. Miras, Marilena Ferbinteanu, Koen Robeyns, Sabir Ouahhoud, Redouan Benabbes, Kai C. Hultzsch, Mariusz Wolff and Yann Garcia

Eur J Inorg Chem, 2024, 27
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Ferrocenyl Quinoline-Benzimidazole Hybrids: A Multistage Strategy to Combat Drug-Resistant Malaria

Taryn M. Golding, Larnelle F. Garnie, Tayla Rabie, Janette Reader, Lyn-Marié Birkholtz, Kathryn J. Wicht and Gregory S. Smith

Inorg. Chem., 2025, 64, 16152
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Cytotoxic Activity of Some Half‐sandwich Rhodium(III) Complexes Containing 4,4’‐disubstituted‐2,2’‐bipyridine Ligands

Marion Graf, Jasmine Ochs, Peter Mayer, Nils Metzler‐Nolte and Hans‐Christian Böttcher

Zeitschrift anorg allge chemie, 2024, 650
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Arene-Ruthenium(II) Complexes with Carbothiamidopyrazoles as a Potential Alternative for Antibiotic Resistance in Human

Ewelina Namiecińska, Magdalena Grazul, Beata Sadowska, Marzena Więckowska-Szakiel, Paweł Hikisz, Beata Pasternak and Elzbieta Budzisz

Molecules, 2022, 27, 468
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Coumarin‐modified ruthenium complexes: Synthesis, characterization, and antiproliferative activity against human cancer cells

Silvio Jakopec, Lejla F. Hamzic, Luka Bočkor, Iris Car, Berislav Perić, Srećko I. Kirin, Mirela Sedić and Silvana Raić‐Malić

Archiv der Pharmazie, 2024, 357
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Non-Extensive Fragmentation of Natural Products and Pharmacophore-Based Virtual Screening as a Practical Approach to Identify Novel Promising Chemical Scaffolds

Andrés Felipe Vásquez, Alejandro Reyes Muñoz, Jorge Duitama and Andrés González Barrios

Front. Chem., 2021, 9
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Recent Studies on the Antimicrobial Activity of Copper Complexes

O. A. Zalevskaya and Y. A. Gur’eva

Russ J Coord Chem, 2021, 47, 861
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Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles

Ishika Saha, Eric K. Dang, Dennis Svatunek, Kendall N. Houk and Patrick G. Harran

Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 24679
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Investigation of bioorganometallic artemisinins as antiplasmodials

Christoff C. Albertyn, Annick van Niekerk, Sandra Duffy, Vicky M. Avery, Erick Strauss and Prinessa Chellan

Journal of Organometallic Chemistry, 2023, 987-988, 122633
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Synthesis of Ortho-Functionalized 1,4-Cubanedicarboxylate Derivatives through Photochemical Chlorocarbonylation

Diego E. Collin, Kristina Kovacic, Mark E. Light and Bruno Linclau

Org. Lett., 2021, 23, 5164
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Evaluation of 3-Dimensionality in Approved and Experimental Drug Space

Kathleen E. Prosser, Ryjul W. Stokes and Seth M. Cohen

ACS Med. Chem. Lett., 2020, 11, 1292
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Metal-based complexes, a promising solution to antimicrobial resistance

B.W.H. Tan and P.F.P. Lee

Letters in Drug Design & Discovery, 2025, 22, 100257
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Fragment-to-Lead Medicinal Chemistry Publications in 2020

Iwan J. P. de Esch, Daniel A. Erlanson, Wolfgang Jahnke, Christopher N. Johnson and Louise Walsh

J. Med. Chem., 2022, 65, 84
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New Antimicrobial Strategies Based on Metal Complexes

Mickaël Claudel, Justine V. Schwarte and Katharina M. Fromm

Chemistry, 2020, 2, 849
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A review on the anti-parasitic activity of ruthenium compounds

Shibam Chakraborty, Sumit Ghosh, Shauryabrota Dalui and Avijit Dey

JoBAZ, 2024, 85
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Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy

Nur Aininie Yusoh, Paul R. Tiley, Steffan D. James, Siti Norain Harun, Jim A. Thomas, Norazalina Saad, Ling-Wei Hii, Suet Lin Chia, Martin R. Gill and Haslina Ahmad

J. Med. Chem., 2023, 66, 6922
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Harnessing Transition Metal Scaffolds for Targeted Antibacterial Therapy

Cheng Weng, Yong Leng Kelvin Tan, Wayne Gareth Koh and Wee Han Ang

Angew Chem Int Ed, 2023, 62
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Optically Pure Double-Stranded Dinuclear Ir(III) Metallohelices Enabled Chirality-Induced Photodynamic Responses

Xuezhao Li, Zhicheng Wang, Xiaorou Hao, Jingyi Zhang, Xing Zhao, Yougang Yao, Wei Wei, Rui Cai, Cheng He, Chunying Duan, Zijian Guo, Jing Zhao and Xiuxiu Wang

J. Am. Chem. Soc., 2023, 145, 14766
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Copper(II) and Zinc(II) Complexes with Bacterial Prodigiosin Are Targeting Site III of Bovine Serum Albumin and Acting as DNA Minor Groove Binders

Lena Pantelic, Sanja Skaro Bogojevic, Tina P. Andrejević, Bojana V. Pantović, Violeta R. Marković, Darko P. Ašanin, Žiko Milanović, Tatjana Ilic-Tomic, Jasmina Nikodinovic-Runic, Biljana Đ. Glišić and Jelena Lazic

IJMS, 2024, 25, 8395
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Quinizarin Gold(I) N‐Heterocyclic Carbene Complexes with Synergistic Activity Against Anthracycline‐Resistant Leukaemia Cells: Synthesis and Biological Activity Studies

Axel Steinbrueck, Matthew L. Reback, Christoph Rumancev, Daniel Siegmund, Jan Garrevoet, Gerald Falkenberg, Axel Rosenhahn, Aram Prokop and Nils Metzler‐Nolte

Chemistry A European J, 2025, 31
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The quest of the best – A SAR study of trithiolato-bridged dinuclear Ruthenium(II)-Arene compounds presenting antiparasitic properties

Emilia Păunescu, Ghalia Boubaker, Oksana Desiatkina, Nicoleta Anghel, Yosra Amdouni, Andrew Hemphill and Julien Furrer

European Journal of Medicinal Chemistry, 2021, 222, 113610
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Cytotoxic Activities of Half‐sandwich M(III) Complexes (M=Rh, Ir) Bearing Chloro‐substituted Bidentate‐coordinated Phenanthroline or Terpyridine Ligands

Marion Graf, Jasmine Ochs, Nils Metzler‐Nolte, Hans‐Christian Böttcher and Peter Mayer

Zeitschrift anorg allge chemie, 2023, 649
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Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties

Sofia Fulgencio, Mirco Scaccaglia and Angelo Frei

ChemBioChem, 2024, 25
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A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis

Martin R. Gill, Paul J. Jarman, Vanessa Hearnden, Simon D Fairbanks, Marcella Bassetto, Hannes Maib, John Palmer, Kathryn R. Ayscough, Jim A. Thomas and Carl Smythe

Angewandte Chemie, 2022, 134
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Synthesis, Investigation, Biological Evaluation, and Application of Coordination Compounds with Schiff Base—A Review

Petya Emilova Marinova and Kristina Dimova Tamahkyarova

Compounds, 2025, 5, 14
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Rational approaches towards inorganic and organometallic antibacterials

Jeannine Hess

Biological Chemistry, 2022, 403, 363
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Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments

Damiano Cirri, Francesco Bartoli, Alessandro Pratesi, Emma Baglini, Elisabetta Barresi and Tiziano Marzo

Biomedicines, 2021, 9, 504
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Structure-Based Identification of Organoruthenium Compounds as Nanomolar Antagonists of Cannabinoid Receptors

Qing Wang, Xuegang Fu, Yuting Yan, Tao Liu, Yuting Xie, Xiaoqing Song, Yu Zhou, Min Xu, Ping Wang, Peng Fu, Jianhui Huang and Niu Huang

J. Chem. Inf. Model., 2024, 64, 761
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A Semi‐Automated, High‐Throughput Approach for the Synthesis and Identification of Highly Photo‐Cytotoxic Iridium Complexes

Timothy Kench, Arielle Rahardjo, Gianmarco G. Terrones, Adinarayana Bellamkonda, Thomas E. Maher, Marko Storch, Heather J. Kulik and Ramon Vilar

Angew Chem Int Ed, 2024, 63
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Copper(II) and Zinc(II) Complexes with the Clinically Used Fluconazole: Comparison of Antifungal Activity and Therapeutic Potential

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