Anti-hyperuricemia bioactive peptides: a review on obtaining, activity, and mechanism of action

Ying Chen, Hongyan Li, Yunfei Cai, Ke Wang and Yousheng Wang

Food Funct., 2024, 15, 5714
DOI: 10.1039/D4FO00760C

Discovery of a novel rice-derived peptide with significant anti-gout potency

Naixin Liu, Buliang Meng, Lin Zeng, Saige Yin, Yan Hu, Shanshan Li, Yang Fu, Xinping Zhang, Chun Xie, Longjun Shu, Meifeng Yang, Ying Wang and Xinwang Yang

Food Funct., 2020, 11, 10542
DOI: 10.1039/D0FO01774D

Isolation, identification and molecular docking of anti-inflammatory peptides from walnut (Juglans regia L.) meal hydrolysates

Yannan Xu, Yanxia Feng, Yulan Yang, Le Cheng, Min Zhou, Yu Guo and Difeng Ren

Food Funct., 2023, 14, 6093
DOI: 10.1039/D3FO00768E

Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice

Haitao Wan, Jiaojiao Han, Shasha Tang, Wei Bao, Chenyang Lu, Jun Zhou, Tinghong Ming, Ye Li and Xiurong Su

Food Funct., 2020, 11, 1074
DOI: 10.1039/C9FO02425E

Anti-hyperuricemic potential of stevia (Stevia rebaudianaBertoni) residue extract in hyperuricemic mice

Arshad Mehmood, Liang Zhao, Muhammad Ishaq, Wang Xin, Lei Zhao, Chengtao Wang, Imam Hossen, Huimin Zhang, Yunhe Lian and Meili Xu

Food Funct., 2020, 11, 6387
DOI: 10.1039/C9FO02246E

Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice

Xiaoyun Qian, Xu Wang, Jing Luo, Yao Liu, Juan Pang, Hanyue Zhang, Zhongliang Xu, Jiewen Xie, Xinwei Jiang and Wenhua Ling

Food Funct., 2019, 10, 867
DOI: 10.1039/C8FO02124D

Hypouricemic, hepatoprotective and nephroprotective roles of oligopeptides derived fromAuxis thazardprotein in hyperuricemic mice

Liuyi Wei, Hongwu Ji, Wenkui Song, Shuo Peng, Suhong Zhan, Yushan Qu, Ming Chen, Di Zhang and Shucheng Liu

Food Funct., 2021, 12, 11838
DOI: 10.1039/D1FO02539B

Using deep learning and molecular dynamics simulations to unravel the regulation mechanism of peptides as noncompetitive inhibitor of xanthine oxidase

Yi He, Kaifeng Liu, Fuyan Cao, Renxiu Song, Jianxuan Liu, Yinghua Zhang, Wannan Li and Weiwei Han

Sci Rep, 2024, 14
DOI: 10.1038/s41598-023-50686-0

The road to reuse of walnut by-products: A comprehensive review of bioactive compounds, extraction and identification methods, biomedical and industrial applications

Kaiyang Zhu, Ji Ma, Junzhao Cong, Ting Zhang, Hongjie Lei, Huaide Xu, Zisheng Luo and Mei Li

Trends in Food Science & Technology, 2024, 143, 104264
DOI: 10.1016/j.tifs.2023.104264

Antihyperuricemic activity and inhibition mechanism of xanthine oxidase inhibitory peptides derived from whey protein by virtual screening

Yaru Xu, Han Gong, Yang Zou and Xueying Mao

Journal of Dairy Science, 2024, 107, 1877
DOI: 10.3168/jds.2023-24028

Antihyperuricemia Bioactive Substances Derived from Marine Organisms

Qian Wang, Dimitrios Stagos and Ming Liu

J. Agric. Food Chem., 2025, 73, 14192
DOI: 10.1021/acs.jafc.5c03143

Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota

Jiaojiao Han, Xiaofeng Wang, Shasha Tang, Chenyang Lu, Haitao Wan, Jun Zhou, Ye Li, Tinghong Ming, Zaijie Jim Wang and Xiurong Su

The FASEB Journal, 2020, 34, 5061
DOI: 10.1096/fj.201902597RR

Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein

Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi and Ying-Hua Zhang

Food Research International, 2023, 169, 112882
DOI: 10.1016/j.foodres.2023.112882

Identification and molecular docking of two novel peptides with xanthine oxidase inhibitory activity from Auxis thazard

Liuyi WEI, Hongwu JI, Wenkui SONG, Shuo PENG, Suhong ZHAN, Yushan QU, Ming CHEN, Di ZHANG and Shucheng LIU

Food Sci. Technol, 2022, 42
DOI: 10.1590/fst.106921

Identification, inhibitory mechanism and transepithelial transport of xanthine oxidase inhibitory peptides from whey protein after simulated gastrointestinal digestion and intestinal absorption

Xiaofen Qi, Haoran Chen, Kaifang Guan, Yue Sun, Rongchun Wang and Ying Ma

Food Research International, 2022, 162, 111959
DOI: 10.1016/j.foodres.2022.111959

Sacha Inchi Oil Press-Cake Protein Hydrolysates Exhibit Anti-Hyperuricemic Activity via Attenuating Renal Damage and Regulating Gut Microbiota

Kun Wang, Shanshan Wu, Pan Li, Nan Xiao, Jiamin Wen, Jinming Lin, Siming Lu, Xin Cai, Yanan Xu and Bing Du

Foods, 2022, 11, 2534
DOI: 10.3390/foods11162534

Food-derived Trp-rich oligopeptides: Production, bioactivities, and structure-function relationship

Jing Wu, Chun Cui and Dongxiao Sun-Waterhouse

Trends in Food Science & Technology, 2024, 143, 104247
DOI: 10.1016/j.tifs.2023.104247

Sustainable bioactive peptides from by-products of woody oil plants: Updated insights into biological functions and molecular modelling

Thanh Ninh Le, Haiying Cai, Yaxuan Shang, Phu Hung Nguyen, Xuezhi Fang, Yu Cao, Zisheng Luo, Jing Wang, Fengqin Feng and Minjie Zhao

Trends in Food Science & Technology, 2026, 168, 105498
DOI: 10.1016/j.tifs.2025.105498

Purification and Identification of Novel Xanthine Oxidase Inhibitory Peptides Derived from Round Scad (Decapterus maruadsi) Protein Hydrolysates

Xiao Hu, Ya Zhou, Shaobo Zhou, Shengjun Chen, Yanyan Wu, Laihao Li and Xianqing Yang

Marine Drugs, 2021, 19, 538
DOI: 10.3390/md19100538

Novel peptides with xanthine oxidase inhibitory activity identified from macadamia nuts: integrated in silico and in vitro analysis

Lei Zhao, Xin Ai, Fei Pan, Na Zhou, Liang Zhao, Shengbao Cai and Xiaoning Tang

Eur Food Res Technol, 2022, 248, 2031
DOI: 10.1007/s00217-022-04028-5

Preparation, functional mechanism, and deep-learning application of food-derived xanthine oxidase-inhibitory peptides: A comprehensive review

Tian Wang, Dangfeng Wang, Likun Ren, Lingling Dang, Zongji Wang, Guilin Zhang, Zhongwei Liu, Yuping Wang, Fenglan Zhu, Xuepeng Li, Yang Jiang, Jianrong Li, Tingting Li and Fangchao Cui

Trends in Food Science & Technology, 2025, 163, 105134
DOI: 10.1016/j.tifs.2025.105134

Walnut-derived peptide mitigates bisphenol AF-induced neurotoxicity in zebrafish: behavioral improvement associated with Cav1/AMPK-PI3K/Akt signaling

Wei Wei, Shuai Wang, Qiming Wu, Xinyong Zheng and Fuguo Liu

Journal of Functional Foods, 2026, 139, 107226
DOI: 10.1016/j.jff.2026.107226

Enzymatic preparation, structural characterization and in vitro uric acid-lowering activity of XOD inhibitory peptides from cottonseed protein

Huihui Zheng, Xiaorong Deng, Lingzhen Ma, Qi Hao, Ting Liu, Zhenghong Zhang, Yongdong Lei and Jian Zhang

Food Bioscience, 2025, 74, 107956
DOI: 10.1016/j.fbio.2025.107956

Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

Jelena Stanisic, Tamara Ivkovic, Snjezana Romic, Manja Zec, Tijana Culafic, Mojca Stojiljkovic and Goran Koricanac

International Journal of Food Sciences and Nutrition, 2021, 72, 324
DOI: 10.1080/09637486.2020.1796931

Food-derived bioactive peptides with anti-hyperuricemic activity: A comprehensive review

Arshad Mehmood, Asra Iftikhar and Xiumin Chen

Food Chemistry, 2024, 451, 139444
DOI: 10.1016/j.foodchem.2024.139444

Research Progress on New Functions of Animal and Plant Proteins

Hao Duan, Gaigai Liu, Duo Feng, Zhuoye Wang and Wenjie Yan

Foods, 2024, 13, 1223
DOI: 10.3390/foods13081223

Separation, identification and docking analysis of xanthine oxidase inhibitory peptides from pacific cod bone-flesh mixture

Qiang Zhao, Ying Meng, Juncai Liu, Zelin Hu, Yutong Du, Jianan Sun and Xiangzhao Mao

LWT, 2022, 167, 113862
DOI: 10.1016/j.lwt.2022.113862

CRISPR/Cas9 System-Mediated Multi-copy Expression of an Alkaline Serine Protease in Aspergillus niger for the Production of XOD-Inhibitory Peptides

Shounan Wang, Yibin Xue, Peng Zhang, Qiaojuan Yan, Yanxiao Li and Zhengqiang Jiang

J. Agric. Food Chem., 2023, 71, 15194
DOI: 10.1021/acs.jafc.3c04138

Anti-Hyperuricemic Effect of Anserine Based on the Gut–Kidney Axis: Integrated Analysis of Metagenomics and Metabolomics

Mairepaiti Halimulati, Ruoyu Wang, Sumiya Aihemaitijiang, Xiaojie Huang, Chen Ye, Zongfeng Zhang, Lutong Li, Wenli Zhu, Zhaofeng Zhang and Lixia He

Nutrients, 2023, 15, 969
DOI: 10.3390/nu15040969

Novel hemoglobin-derived xanthine oxidase inhibitory peptides: Enzymatic preparation and inhibition mechanisms

Peng Zhang, Zhengqiang Jiang, Jia Lei, Qiaojuan Yan and Chang Chang

Journal of Functional Foods, 2023, 102, 105459
DOI: 10.1016/j.jff.2023.105459

Walnut Protein: A Rising Source of High-Quality Protein and Its Updated Comprehensive Review

Chaoting Wen, Zhiyi Zhang, Liyan Cao, Guoyan Liu, Li Liang, Xiaofang Liu, Jixian Zhang, Youdong Li, Xinquan Yang, Shugang Li, Jiaoyan Ren and Xin Xu

J. Agric. Food Chem., 2023, 71, 10525
DOI: 10.1021/acs.jafc.3c01620

The human gut microbiota and uric acid metabolism: genes, metabolites, and diet

Lei Sun, Min Zhang, Jianxin Zhao, Wei Chen and Gang Wang

Critical Reviews in Food Science and Nutrition, 2025, 65, 7612
DOI: 10.1080/10408398.2025.2475238

The hypouricemic effect and mechanism of tuna (Thunnus albacares) peptide and screening its functional peptide segments

Yifan Wang, Junhao Wu, Lu Lu, Beicheng Fang, Minjie Zhao, Fengqin Feng and Jing Wang

Food Research International, 2025, 221, 117181
DOI: 10.1016/j.foodres.2025.117181

Production, bioactivities and bioavailability of bioactive peptides derived from walnut origin by-products: a review

Dandan Liu, Yiting Guo and Haile Ma

Critical Reviews in Food Science and Nutrition, 2023, 63, 8032
DOI: 10.1080/10408398.2022.2054933

A comprehensive review of specific activity and intrinsic connections of food‐derived bioactive peptides for human health

Tiantian Zhao, Guowan Su, Lijun Zhang, Jieqiong Chen, Yehui Zhang, Weifeng Liu, Mouming Zhao, Jianan Zhang and Qingrong Huang

Food Frontiers, 2024, 5, 1145
DOI: 10.1002/fft2.373

Modulation of NLRP3 inflammasome and uric acid metabolism by small molecule pectin from Premna ligustroides Hemsl leaves: Implications for hyperuricemia management

Liling Deng, Rui He, Jingxin Mao, Heng Yang, Qinhong Shi, Yongbo Peng and Geng Zhong

International Journal of Biological Macromolecules, 2025, 331, 148214
DOI: 10.1016/j.ijbiomac.2025.148214

Pentapeptide WN5 targets the gut microbiota in alleviating Alzheimer’s disease pathologies

William Kwame Amakye, Zhengyu Ren, Min Wang, Maojin Yao and Jiaoyan Ren

Nutrition and Healthy Aging, 2023, 8, 19
DOI: 10.3233/NHA-220168

Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein

Feng Ma, Shili Sun, Haoduo Ye, Zhenyu Zhang, Qimiao Chen, Shouwei Yin, Yong Cao and Jianyin Miao

Food Bioscience, 2024, 61, 104512
DOI: 10.1016/j.fbio.2024.104512

Bioactive anti-aging agents and the identification of new anti-oxidant soybean peptides

William Kwame Amakye, Chuanli Hou, Liping Xie, Xiaoling Lin, Na Gou, Erdong Yuan and Jiaoyan Ren

Food Bioscience, 2021, 42, 101194
DOI: 10.1016/j.fbio.2021.101194

Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia: a review

Kaina Qiao, Xuewei Zhou, Lili Zhang, Wangang Zhang, Baoguo Sun and Yuyu Zhang

Food Science and Human Wellness, 2025, 14, 9250054
DOI: 10.26599/FSHW.2024.9250054

Exploring the potential of novel xanthine oxidase inhibitory peptide (ACECD) derived from Skipjack tuna hydrolysates using affinity-ultrafiltration coupled with HPLC–MALDI-TOF/TOF-MS

Hao Zhong, Abdullah, Yipeng Zhang, Lingli Deng, Minjie Zhao, Jun Tang, Hui Zhang, Fengqin Feng and Jing Wang

Food Chemistry, 2021, 347, 129068
DOI: 10.1016/j.foodchem.2021.129068

Walnut‐Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice

Min Wang, William Kwame Amakye, Lu Guo, Congcong Gong, Yuanhui Zhao, Maojin Yao and Jiaoyan Ren

Molecular Nutrition Food Res, 2019, 63
DOI: 10.1002/mnfr.201900326

Identification of an Anti-inflammatory Peptide from Walnut (Juglans sigillata) Protein and the Effect on DSS-Induced Colitis in Mice

Pengtao Huan, Yujie Zhong, Ting Ma, Yongliang Zhuang, Shupeng Chen, Hongyu Pan, Delu Ning and Liping Sun

J. Agric. Food Chem., 2026, 74, 7621
DOI: 10.1021/acs.jafc.5c15462

Amino Acid Patterns that Determine Antihyperuricemic Activity of Peptides: Identification and Predictive Analysis

Anastasia Smirnova and Sergey Tikhonov

Food Processing: Techniques and Technology, 2024, 687
DOI: 10.21603/2074-9414-2024-4-2536

Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects

Yu Han, Wanlu Liu, Kexin Li, Mingzhen Zhang, Xinqi Liu, Lu Li, Zhao Guo and He Li

Foods, 2024, 14, 58
DOI: 10.3390/foods14010058

Interaction-based screening, Monte Carlo Bayesian inference-based de novo design and in vitro verification of adenine-binding peptide

Wanqian Sha, Congcong Gong, Ganhong Xiao, Chuanli Hou and Jiaoyan Ren

Food Chemistry, 2024, 448, 139076
DOI: 10.1016/j.foodchem.2024.139076

Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Linwei He, Wenjian Yang and Jianhui Liu

Food Chemistry International, 2025, 1, 216
DOI: 10.1002/fci2.70019

New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats

Naixin Liu, Ying Wang, Meifeng Yang, Wenxin Bian, Lin Zeng, Saige Yin, Ziqian Xiong, Yan Hu, Siyuan Wang, Buliang Meng, Jun Sun and Xinwang Yang

J. Agric. Food Chem., 2019, 67, 220
DOI: 10.1021/acs.jafc.8b05879

Систематизация научных знаний о биоактивных пептидах-ингибиторах ксантиноксидазы гиперурикемического действия

Анастасия Вадимовна Смирнова

АПК России, 2023, 30, 96
DOI: 10.55934/10.55934/2587-8824-2022-30-1-96-107

Bioactive Peptides from Walnut Residue Protein

Xiangyang Li, Manli Guo, Jingtian Chi and Jiangang Ma

Molecules, 2020, 25, 1285
DOI: 10.3390/molecules25061285

Anti‐hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats

Xiaofen Qi, Haoran Chen, Kaifang Guan, Rongchun Wang and Ying Ma

J Sci Food Agric, 2021, 101, 4916
DOI: 10.1002/jsfa.11135

Xanthine Oxidase Inhibitory Peptides from Larimichthys polyactis: Characterization and In Vitro/In Silico Evidence

Xiaoling Chen, Weiliang Guan, Yujin Li, Jinjie Zhang and Luyun Cai

Foods, 2023, 12, 982
DOI: 10.3390/foods12050982

Novel XO inhibitory peptides from tiger shrimp (Penaeus monodon): Exploration, sequence optimization, inhibition type and molecular mechanism analysis

Qingze Sun, Ni Wang, Qiang Zhao, Shixin Hua, Bowen Xu, Haiyang Zhang and Jianan Sun

Food Chemistry, 2026, 510, 148589
DOI: 10.1016/j.foodchem.2026.148589

Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase

Jun Jiang, Zhengqiang Jiang, Qiaojuan Yan, Susu Han and Shaoqing Yang

Marine Drugs, 2023, 21, 208
DOI: 10.3390/md21040208

Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity

Xin Zhang, Jie Cui, Junling Hou and Wenquan Wang

J. Agric. Food Chem., 2022, 70, 15647
DOI: 10.1021/acs.jafc.2c06554

Isolation and Structure Elucidation of Uric Acid Lowering Lipopeptides from an Okeania sp. Marine Cyanobacterium

Sein Higa, Kazumasa Yagisawa, Noriyuki Natsume, Naoaki Kurisawa, Kiyotake Suenaga and Toshiaki Teruya

J. Nat. Prod., 2025, 88, 2526
DOI: 10.1021/acs.jnatprod.5c01074

Exploration, sequence optimization and inhibition mechanisms of xanthine oxidase inhibitory peptides from chicken hemoglobin

Jun Li, Shiqin Lai, Wen Hu, Jiaxian Liu, Jinming Peng, Dengle Duan, Yan Fan, Qin Wang, Gengsheng Xiao, Ying Zhang and Wenhua Yang

Food Research International, 2026, 223, 117870
DOI: 10.1016/j.foodres.2025.117870

Separation, identification and molecular binding mechanism of dipeptidyl peptidase IV inhibitory peptides derived from walnut (Juglans regia L.) protein

Xiangzhen Kong, Lina Zhang, Weiguang Song, Caimeng Zhang, Yufei Hua, Yeming Chen and Xingfei Li

Food Chemistry, 2021, 347, 129062
DOI: 10.1016/j.foodchem.2021.129062

Tryptophan residue enhances in vitro walnut protein-derived peptides exerting xanthine oxidase inhibition and antioxidant activities

Qingyong Li, Chuanchao Shi, Min Wang, Mao Zhou, Ming Liang, Ting Zhang, Erdong Yuan, Zhi Wang, Maojin Yao and Jiaoyan Ren

Journal of Functional Foods, 2019, 53, 276
DOI: 10.1016/j.jff.2018.11.024

How Healthy Are Non-Traditional Dietary Proteins? The Effect of Diverse Protein Foods on Biomarkers of Human Health

Caroline Bull, Damien Belobrajdic, Sara Hamzelou, Darren Jones, Wayne Leifert, Rocío Ponce-Reyes, Netsanet Shiferaw Terefe, Gemma Williams and Michelle Colgrave

Foods, 2022, 11, 528
DOI: 10.3390/foods11040528

Metabolic fate of an antihyperuricemic peptide, Tyr-Leu-Asp-Asn-Tyr (YLDNY), upon ingestion in rats

Wei Lin, Tomoko T. Asai, Itsuki Murota and Kenji Sato

Journal of Food Bioactives, 2025, 24
DOI: 10.26599/JFB.2025.95032429

Isolation and identification of xanthine oxidase inhibitory peptides from fish maw: In silico screening, molecular docking, and DFT quantum computations

Meitong Ye, Canmei Hu, Hao Guo, Yuqing Tan, Yongkang Luo and Hui Hong

Food Bioscience, 2025, 72, 107515
DOI: 10.1016/j.fbio.2025.107515

Probiotics, bioactive compounds and dietary patterns for the effective management of hyperuricemia: a review

Lei Sun, Caixin Ni, Jianxin Zhao, Gang Wang and Wei Chen

Critical Reviews in Food Science and Nutrition, 2024, 64, 2016
DOI: 10.1080/10408398.2022.2119934

In silico identification and experimental validation of two types of angiotensin-converting enzyme (ACE) and xanthine oxidase (XO) milk inhibitory peptides

Zekun Li, Wenhua Zhang, Mohamed Aamer Abubaker, Qin Shu and Yongfeng Liu

Food Chemistry, 2025, 464, 141864
DOI: 10.1016/j.foodchem.2024.141864

Identification of Hyperuricemia Alleviating Peptides from Yellow Tuna Thunnus albacares

Li Hao, Yulian Ding, Yan Fan, Qiaoji Tian, Yang Liu, Yueting Guo, Jian Zhang and Hu Hou

J. Agric. Food Chem., 2024, 72, 12083
DOI: 10.1021/acs.jafc.3c09901

The mechanism of honeysuckle peptides in ameliorating hyperuricemia in mice via the PGC-1α/PPARγ/ABCG2 pathway

Hongxuan Yang, Yun Liang, Yue'e Chen, Lin Liu, Yingfang Wang, Qiting Dou, Jinmei Gong, Zijing Liao, Junqiu Dong and Xuguang Hu

Journal of Ethnopharmacology, 2026, 362, 121358
DOI: 10.1016/j.jep.2026.121358

Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

Yanxin Wang, Mingxia Ma, Yumeng Huang, Siqing Fan, Jie Peng, Shiming Li, Xiurong Su, Yanbo Wang and Chenyang Lu

Food Science and Human Wellness, 2024, 13, 1767
DOI: 10.26599/FSHW.2022.9250149

Promoting walnut protein as a precursor of bioactive peptides: The assisting role of high hydrostatic pressure

Xiaoling Wang, Shuguang Wang, Mouming Zhao, Yao Tang, Liping Sun, Yongliang Zhuang and Bifen Chen

Food Bioscience, 2025, 74, 107858
DOI: 10.1016/j.fbio.2025.107858

Combining bioinformatic prediction and assay experiment to identify novel xanthine oxidase inhibitory peptides from Pacific bluefin tuna (Thunnus Orientalis)

Ying Bu, Fei Wang, Wenhui Zhu, Xuepeng Li, L. Yang and Z. Xu

E3S Web Conf., 2020, 185, 04062
DOI: 10.1051/e3sconf/202018504062

Research on the optimal design technology of a digital assembly sequence based on an internet of things data collection framework

Yan Cao, Liang Huang and Zhuanxia Li

Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, 2021, 235, 715
DOI: 10.1177/0954405420953298

Novel potential XOD inhibitory peptides derived from Trachinotus ovatus: Isolation, identification and structure-function analysis

Mengfan Hou, Huan Xiang, Xiao Hu, Shengjun Chen, Yanyan Wu, Jiachao Xu and Xianqing Yang

Food Bioscience, 2022, 47, 101639
DOI: 10.1016/j.fbio.2022.101639

Recent Advances in the Application of Foodborne Substances in Hyperuricemia

Yanxia Liu, Wei Deng, Fashan Wei, Xiangtao Kang, Ruili Han, Xianchao Feng, Chuang Li, Miaoyun Li, Gaiming Zhao, Jiahuan Yu and Chun Liu

J. Agric. Food Chem., 2024, 72, 27639
DOI: 10.1021/acs.jafc.4c07267

Xanthine oxidase inhibitory peptides derived from tuna protein: virtual screening, inhibitory activity, and molecular mechanisms

Zhipeng Yu, Ruotong Kan, Sijia Wu, Hui Guo, Wenzhu Zhao, Long Ding, Fuping Zheng and Jingbo Liu

J Sci Food Agric, 2021, 101, 1349
DOI: 10.1002/jsfa.10745

Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats

Xiaofen Qi, Kaifang Guan, Chunhong Liu, Haoran Chen, Ying Ma and Rongchun Wang

Journal of Dairy Science, 2023, 106, 7367
DOI: 10.3168/jds.2023-23369

Virtual screening and structure optimization of xanthine oxidase inhibitory peptides from whole protein sequences of Pacific white shrimp via molecular docking

Zhenjie Mao, Hong Jiang, Jianan Sun and Xiangzhao Mao

Food Chemistry, 2023, 429, 136837
DOI: 10.1016/j.foodchem.2023.136837

Understanding Hyperuricemia: Pathogenesis, Potential Therapeutic Role of Bioactive Peptides, and Assessing Bioactive Peptide Advantages and Challenges

Yanchao Chen, Jing Yang, Qinchun Rao, Chen Wang, Xiaoyong Chen, Yu Zhang, Huayi Suo and Jiajia Song

Foods, 2023, 12, 4465
DOI: 10.3390/foods12244465

Extraction of antimicrobial peptides from pea protein hydrolysates by sulfonic acid functionalized biochar

Min Liu, Xian-Da Hu, Xiang-Yu Huang, Li Wen, Zhou Xu, Li Ding, Yun-Hui Cheng and Mao-Long Chen

Food Chemistry, 2025, 463, 141162
DOI: 10.1016/j.foodchem.2024.141162

Prediction and evaluation of purine-binding peptides using integrated molecular descriptors and docking analysis

Jun Zhong, Yongzhao Xu, Ganhong Xiao, Congcong Gong and Jiaoyan Ren

International Journal of Biological Macromolecules, 2025, 306, 141209
DOI: 10.1016/j.ijbiomac.2025.141209

Identification of egg protein-derived peptides as xanthine oxidase inhibitors: virtual hydrolysis, molecular docking, and in vitro activity evaluation

Zhipeng Yu, Yaxin Cao, Ruotong Kan, Huizhuo Ji, Wenzhu Zhao, Sijia Wu, Jingbo Liu and David Shiuan

Food Science and Human Wellness, 2022, 11, 1591
DOI: 10.1016/j.fshw.2022.06.017

Enzymatic Hydrolysis Optimization of Yak Whey Protein Concentrates and Bioactivity Evaluation of the Ultrafiltered Peptide Fractions

Lingshen Hao, Xuefei Li, Baotang Zhao, Xuemei Song, Yan Zhang and Qi Liang

Molecules, 2024, 29, 1403
DOI: 10.3390/molecules29061403

Dual anti-hyperuricemic and anti-gout effects of novel peptides: Xanthine oxidase inhibition, digestive properties, and TLRs-NF-κB pathway suppression in cellular models

Li Hao, Qiaoji Tian, Shiqi Li, Tingting Yang and Hu Hou

Food Bioscience, 2025, 72, 107488
DOI: 10.1016/j.fbio.2025.107488

Beneficial effect and mechanism of walnut oligopeptide on Lactobacillus plantarum Z7

Ting Ding and Yong Li

Food Science & Nutrition, 2021, 9, 672
DOI: 10.1002/fsn3.2029

Purification, identification, and computational analysis of xanthine oxidase inhibitory peptides from kidney bean

Yuqun Wu, Hui He and Tao Hou

Journal of Food Science, 2021, 86, 1081
DOI: 10.1111/1750-3841.15603

Whey protein peptide PEW attenuates hyperuricemia and associated renal inflammation in potassium oxonate and hypoxanthine-induced rat

Xiaofen Qi, Yanfeng Ma, Kaifang Guan, Chunhong Liu, Rongchun Wang, Ying Ma and Tianjiao Niu

Food Bioscience, 2023, 51, 102311
DOI: 10.1016/j.fbio.2022.102311

Mechanisms Associated With Renal Injury in Hyperuricemia and Strategies for the Development of Natural Active Substances

Wanping Lv, Huixiang Chen, Pan Zhou, Aihua Du and Yu Lei

Int J of Rheum Dis, 2025, 28
DOI: 10.1111/1756-185X.70096

Recent Advances in Alleviating Hyperuricemia Through Dietary Sources: Bioactive Ingredients and Structure–activity Relationships

Jun Li, Jinwei Li and Liuping Fan

Food Reviews International, 2023, 39, 6746
DOI: 10.1080/87559129.2022.2124414

Antihyperuricemic effect of tuna protein hydrolysate and derived products after in vitro digestion or Maillard reaction on oteracil potassium‐induced hyperuricemia rats

Yang Liu, Jing Zou, Yaqi Zhao, Dongxiao Sun‐Waterhouse, Mouming Zhao and Guowan Su

Int J of Food Sci Tech, 2019, 54, 263
DOI: 10.1111/ijfs.13970

A novel high-throughput screening strategy for identification of highly active xanthine oxidase inhibitory peptides

Arshia Amjad, Rongchao Wang, Li Zhao, Lei Du and Jingli Xie

Journal of Molecular Structure, 2026, 1353, 144666
DOI: 10.1016/j.molstruc.2025.144666

In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms

Jun Li, Yuhong Gong, Jinwei Li and Liuping Fan

Food Bioscience, 2022, 47, 101711
DOI: 10.1016/j.fbio.2022.101711

Harnessing Protein Hydrolysates and Peptides for Hyperuricemia Management: Insights into Sources, Mechanisms, Techniques, and Future Directions

Xiaoyu Liu, Lei Zhang, Boyin Lai, Jingming Li, Jiachen Zang and Liyan Ma

J. Agric. Food Chem., 2024, 72, 18758
DOI: 10.1021/acs.jafc.4c03605

Virtual screening and directional preparation of xanthine oxidase inhibitory peptides derived from hemp seed protein

Xiaoni Huang, Jiajun Liao, Ping Shi, Xiaodong Pei and Chenghua Wang

Food Science and Human Wellness, 2024, 13, 3652
DOI: 10.26599/FSHW.2023.9250047

Advances on the Antioxidant Peptides from Nuts: A Narrow Review

Fanrui Zhao, Chunlei Liu, Laura Bordoni, Irene Petracci, Dan Wu, Li Fang, Ji Wang, Xiyan Wang, Rosita Gabbianelli and Weihong Min

Antioxidants, 2022, 11, 2020
DOI: 10.3390/antiox11102020

RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice

Naixin Liu, Ying Wang, Lin Zeng, Saige Yin, Yan Hu, Shanshan Li, Yang Fu, Xinping Zhang, Chun Xie, Longjun Shu, Yilin Li, Huiling Sun, Meifeng Yang, Jun Sun and Xinwang Yang

J. Agric. Food Chem., 2020, 68, 7143
DOI: 10.1021/acs.jafc.0c02535

Protease-Catalyzed Rational Synthesis of Uric Acid-Lowering Peptides in Non-aqueous Medium

Xiao-Ni Huang, Yan-Mei Zhang, You Wen, Yi Jiang and Cheng-Hua Wang

Int J Pept Res Ther, 2022, 28
DOI: 10.1007/s10989-022-10367-4

In vitro experiments and computer simulation techniques on the identification, screening and inhibition mechanism of xanthine oxidase (XO) inhibitory peptides from Esox lucius bone

Rui Geng, Yabo Wei, Yi Wang, Xin Guo, Xiaorong Deng, Lianfu Zhang and Jian Zhang

Food Bioscience, 2025, 68, 106610
DOI: 10.1016/j.fbio.2025.106610

Novel Xanthine Oxidase Inhibitory Peptides Derived from Whey Protein: Identification, in Vitro Inhibition Mechanism and in Vivo Activity Validation

Xiaofen Qi, Haoran Chen, Kaifang Guan, Yue Sun, Rongchun Wang, Qiming Li and Ying Ma

SSRN Journal, 2022
DOI: 10.2139/ssrn.4120097

Anti‐Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α‐Lactalbumin on Potassium Oxonate‐ and Hypoxanthine‐Induced Hyperuricemic Mice

Dewei Xie, Yaling Shen, Erzheng Su, Lei Du, Jingli Xie and Dongzhi Wei

Molecular Nutrition Food Res, 2023, 67
DOI: 10.1002/mnfr.202200162

Novel bioprocessing strategies and evaluation models for walnut meal bioactives

Fengling Tan, Yachun Chen, Bing Qi, Siting Li, Zhou Chen, Aijin Ma and Yingmin Jia

Food Chemistry: X, 2026, 34, 103670
DOI: 10.1016/j.fochx.2026.103670

Identification, taste characterization and molecular docking study of novel umami peptides from the Chinese anchovy sauce

Wenhui Zhu, Hongwei Luan, Ying Bu, Xuepeng Li, Jianrong Li and Yuyu Zhang

J Sci Food Agric, 2021, 101, 3140
DOI: 10.1002/jsfa.10943

Systematic investigation of the amino acid profiles that are correlated with xanthine oxidase inhibitory activity: Effects, mechanism and applications in protein source screening

Yumeng Huang, Siqing Fan, Guoding Lu, Na Sun, Rui Wang, Chenyang Lu, Jiaojiao Han, Jun Zhou, Ye Li, Tinghong Ming and Xiurong Su

Free Radical Biology and Medicine, 2021, 177, 326
DOI: 10.1016/j.freeradbiomed.2021.11.004

Rapidly and Efficiently Screening and Identification of Xanthine Oxidase Inhibitory Peptides From Protein Hydrolysate of Antarctic Krill

Xue Liu, Wenya Meng, Jing Zhang, Ye Wang, Long Xing, Huiyang Yu, Hu Hou, Ping Dong and Hong-Ju He

Journal of Food Biochemistry, 2025, 2025
DOI: 10.1155/jfbc/9735450

Response surface optimization of selenium-enriched Moringa oleifera seed peptides with antioxidant, ACEI and XOI activities

Bingbing Chen, Zhen Xia, Haoduo Ye, Qiaoe Wang, Wen Huang, Lingyu Zhang, Wenhao Chen, Dong Liang, Xingtang Liang, Yanzhen Yin, Yong Cao and Jianyin Miao

Food Measure, 2023, 17, 1289
DOI: 10.1007/s11694-022-01690-x

Whey Protein Peptide Pro-Glu-Trp Ameliorates Hyperuricemia by Enhancing Intestinal Uric Acid Excretion, Modulating the Gut Microbiota, and Protecting the Intestinal Barrier in Rats

Xiaofen Qi, Yanfeng Ma, Kaifang Guan, Le Zhao, Ying Ma and Rongchun Wang

J. Agric. Food Chem., 2024, 72, 2573
DOI: 10.1021/acs.jafc.3c00984

Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, in vitro inhibition mechanism and in vivo activity validation

Xiaofen Qi, Haoran Chen, Kaifang Guan, Yue Sun, Rongchun Wang, Qiming Li and Ying Ma

Bioorganic Chemistry, 2022, 128, 106097
DOI: 10.1016/j.bioorg.2022.106097

Food-derived natural compounds in the management of chronic diseases via Wnt signaling pathway

Li Gao, Na Gou, Maojin Yao, William Kwame Amakye and Jiaoyan Ren

Critical Reviews in Food Science and Nutrition, 2022, 62, 4769
DOI: 10.1080/10408398.2021.1879001

Progress in the preparation, identification and biological activity of walnut peptides

Chang Liu, Zijie Zhang, Yuting Shang, Siting Li, Junxia Xia, Yiling Tian, Yingmin Jia and Aijin Ma

Journal of Future Foods, 2024, 4, 205
DOI: 10.1016/j.jfutfo.2023.07.003

Food-Derived Bioactive Peptides with Antioxidative Capacity, Xanthine Oxidase and Tyrosinase Inhibitory Activity

Anthony Thaha, Bor-Sen Wang, Yu-Wei Chang, Shih-Min Hsia, Tsui-Chin Huang, Chyuan-Yuan Shiau, Deng-Fwu Hwang and Tai-Yuan Chen

Processes, 2021, 9, 747
DOI: 10.3390/pr9050747