On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent

Sarah Spreckelmeyer, Natalia Estrada-Ortiz, Gerian G. H. Prins, Margot van der Zee, Bente Gammelgaard, Stefan Stürup, Inge A. M. de Graaf, Geny M. M. Groothuis and Angela Casini

Metallomics, 2017, 9, 1786
DOI: 10.1039/C7MT00271H

The CRISPR-Cas9 system: a promising tool for discovering potential approaches to overcome drug resistance in cancer

Jiayu Zhang, Wenlong Zhou, Xiaoxuan Wang and Lihui Wang

RSC Adv., 2018, 8, 33464
DOI: 10.1039/C8RA04509G

Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Xiao-xia Ban, Hao Wan, Xin-xing Wan, Ya-ting Tan, Xi-min Hu, Hong-xia Ban, Xin-yu Chen, Kun Huang, Qi Zhang and Kun Xiong

CURR MED SCI, 2024, 44, 28
DOI: 10.1007/s11596-024-2832-z

Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity

Debashree Mukherjea, Asmita Dhukhwa, Amit Sapra, Priyanka Bhandari, Katlyn Woolford, Jacob Franke, Vickram Ramkumar and Leonard Rybak

Expert Opinion on Drug Metabolism & Toxicology, 2020, 16, 965
DOI: 10.1080/17425255.2020.1806235

Anticancer Potential of Cinnamon Bark Extract (Cinnamomum burmanii) with Cisplatin Combination against P-glycoprotein and Apoptotic Influx Biomarkers

Sarah Dina, M. Fidel Ganis Siregar, Nelva K. Jusuf, Poppy Anjelisa Hasibuan, Andrijono Andrijono, Adang Bachtiar, Sarma N. Lumbanraja and Iqbal Pahlevi Nasution

Open Access Maced J Med Sci, 2022, 10, 958
DOI: 10.3889/oamjms.2022.9420

Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1

Rachel Curnock and Peter J. Cullen

Journal of Cell Science, 2020, 133
DOI: 10.1242/jcs.249201

Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer

Justyna Suwara and Mariusz L. Hartman

J Exp Clin Cancer Res, 2025, 44
DOI: 10.1186/s13046-025-03486-5

Targeting of copper-trafficking chaperones causes gene-specific systemic pathology inDrosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin

Eleni I. Theotoki, Athanassios D. Velentzas, Stamatia A. Katarachia, Nikos C. Papandreou, Nikolas I. Kalavros, Sofia N. Pasadaki, Aikaterini F. Giannopoulou, Panagiotis Giannios, Vassiliki Iconomidou, Eumorphia G. Konstantakou, Ema Anastasiadou, Issidora S. Papassideri and Dimitrios J. Stravopodis

Biology Open, 2019
DOI: 10.1242/bio.046961

Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

Sarah Spreckelmeyer, Margot van der Zee, Benoît Bertrand, Ewen Bodio, Stefan Stürup and Angela Casini

Front. Chem., 2018, 6
DOI: 10.3389/fchem.2018.00377

Application of Approved Cisplatin Derivatives in Combination Therapy against Different Cancer Diseases

Dobrina Tsvetkova and Stefka Ivanova

Molecules, 2022, 27, 2466
DOI: 10.3390/molecules27082466

Copper metabolism as a unique vulnerability in cancer

Vinit C. Shanbhag, Nikita Gudekar, Kimberly Jasmer, Christos Papageorgiou, Kamal Singh and Michael J. Petris

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021, 1868, 118893
DOI: 10.1016/j.bbamcr.2020.118893

The Rationale for “Laser-Induced Thermal Therapy (LITT) and Intratumoral Cisplatin” Approach for Cancer Treatment

Renan Vieira de Brito, Marília Wellichan Mancini, Marcel das Neves Palumbo, Luis Henrique Oliveira de Moraes, Gerson Jhonatan Rodrigues, Onivaldo Cervantes, Joel Avram Sercarz and Marcos Bandiera Paiva

IJMS, 2022, 23, 5934
DOI: 10.3390/ijms23115934

Copper in Gynecological Diseases

Rocío A. Conforti, María B. Delsouc, Edith Zorychta, Carlos M. Telleria and Marilina Casais

IJMS, 2023, 24, 17578
DOI: 10.3390/ijms242417578

Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics

Sergey Tsymbal, Ge Li, Nikol Agadzhanian, Yuhao Sun, Jiazhennan Zhang, Marina Dukhinova, Viacheslav Fedorov and Maxim Shevtsov

Molecules, 2022, 27, 7066
DOI: 10.3390/molecules27207066

Copper transporters and copper chaperones: roles in cardiovascular physiology and disease

Tohru Fukai, Masuko Ushio-Fukai and Jack H. Kaplan

American Journal of Physiology-Cell Physiology, 2018, 315, C186
DOI: 10.1152/ajpcell.00132.2018

Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy

Jordon M. Inkol, Andrew C. Poon and Anthony J. Mutsaers

Vet Comparative Oncology, 2020, 18, 559
DOI: 10.1111/vco.12579

Targeting STAT3 inhibition to reverse cisplatin resistance

Chao-Yue Sun, Juan Nie, Jie-Peng Huang, Guang-Juan Zheng and Bing Feng

Biomedicine & Pharmacotherapy, 2019, 117, 109135
DOI: 10.1016/j.biopha.2019.109135

Exploring the Extended Biological Functions of the Human Copper Chaperone of Superoxide Dismutase 1

Yan Ge, Lu Wang, Duanhua Li, Chen Zhao, Jinjun Li and Tao Liu

Protein J, 2019, 38, 463
DOI: 10.1007/s10930-019-09824-9

Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer

Xin Wen, Shui Liu, Jiyao Sheng and Manhua Cui

PeerJ, 2020, 8, e9234
DOI: 10.7717/peerj.9234

Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs

Ian Henry Lambert and Belinda Halling Sørensen

IJMS, 2018, 19, 2249
DOI: 10.3390/ijms19082249

Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

Rachel M Hurley, Cordelia D McGehee, Ksenija Nesic, Cristina Correia, Taylor M Weiskittel, Rebecca L Kelly, Annapoorna Venkatachalam, Xiaonan Hou, Nicholas M Pathoulas, X Wei Meng, Olga Kondrashova, Marc R Radke, Paula A Schneider, Karen S Flatten, Kevin L Peterson, Marc A Becker, Ee Ming Wong, Melissa S Southey, Alexander Dobrovic, Kevin K Lin, Thomas C Harding, Iain McNeish, Christian A Ross, Jill M Wagner, Matthew J Wakefield, Clare L Scott, Paul Haluska, Andrea E Wahner Hendrickson, Larry M Karnitz, Elizabeth M Swisher, Hu Li, S John Weroha and Scott H Kaufmann

NAR Cancer, 2021, 3
DOI: 10.1093/narcan/zcab028

Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells

Sarah Guttmann, Gursimran Chandhok, Sara Reinartz Groba, Christoph Niemietz, Vanessa Sauer, Amanda Gomes, Giuliano Ciarimboli, Uwe Karst, Andree Zibert and Hartmut H. Schmidt

Oncotarget, 2018, 9, 743
DOI: 10.18632/oncotarget.23142

The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin

Timothée Rivel, Christophe Ramseyer and Semen Yesylevskyy

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-41903-w

Evaluating H2BC9 as a potential diagnostic and prognostic biomarker in head and neck squamous cell carcinoma

Lanhua Wu, Liang Li, Mingjing Zhu, Ziyan Zhou, Xuejin Su, Yueming Jiang, Min Kang and Li Jiang

Eur J Med Res, 2025, 30
DOI: 10.1186/s40001-025-02301-3

The molecular and cellular basis of copper dysregulation and its relationship with human pathologies

May T. Maung, Alyssa Carlson, Monserrat Olea‐Flores, Lobna Elkhadragy, Kyle M. Schachtschneider, Napoleon Navarro‐Tito and Teresita Padilla‐Benavides

The FASEB Journal, 2021, 35
DOI: 10.1096/fj.202100273RR

Copper homeostasis as target of both consolidated and innovative strategies of anti-tumor therapy

Anastasia De Luca, Anna Barile, Mario Arciello and Luisa Rossi

Journal of Trace Elements in Medicine and Biology, 2019, 55, 204
DOI: 10.1016/j.jtemb.2019.06.008

Copper in tumors and the use of copper-based compounds in cancer treatment

Daniela Almeida da Silva, Anastasia De Luca, Rosanna Squitti, Mauro Rongioletti, Luisa Rossi, Camila M.L. Machado and Giselle Cerchiaro

Journal of Inorganic Biochemistry, 2022, 226, 111634
DOI: 10.1016/j.jinorgbio.2021.111634

Genetic polymorphisms as potential pharmacogenetic biomarkers for platinum-based chemotherapy in non-small cell lung cancer

Hilary Sito and Shing Cheng Tan

Mol Biol Rep, 2024, 51
DOI: 10.1007/s11033-023-08915-2

Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi and Wenyi Wei

Advanced Science, 2021, 8
DOI: 10.1002/advs.202004303

Cuproptosis to Cuproptosis‐Like: Therapeutic Strategies for Bacterial Infection

Wenqi Wang, Hengshuo Gui, Xiaolong Wei, Huiyu Liu and Xianwen Wang

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202506119

CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences

Ekaterina Y. Ilyechova, Elisa Bonaldi, Iurii A. Orlov, Ekaterina A. Skomorokhova, Ludmila V. Puchkova and Massimo Broggini

Cells, 2019, 8, 322
DOI: 10.3390/cells8040322

Application of CRISPR-Cas9 System to Study Biological Barriers to Drug Delivery

Ji He, Riya Biswas, Piyush Bugde, Jiawei Li, Dong-Xu Liu and Yan Li

Pharmaceutics, 2022, 14, 894
DOI: 10.3390/pharmaceutics14050894

Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers

Vivek Kaushik, Juan Sebastian Yakisich, Anil Kumar, Neelam Azad and Anand K. V. Iyer

Cancers, 2018, 10, 360
DOI: 10.3390/cancers10100360

In vitro and in vivo accumulation of the anticancer Ru complexes [RuII(cym)(HQ)Cl] and [RuII(cym)(PCA)Cl]Cl

Mie Riisom, Stuart J. Morrow, Caitlin D. Herbert, William D. J. Tremlett, Jonathan W. Astin, Stephen M. F. Jamieson and Christian G. Hartinger

J Biol Inorg Chem, 2023, 28, 767
DOI: 10.1007/s00775-023-02026-w

Copper signalling: causes and consequences

Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács and Katalin Jemnitz

Cell Commun Signal, 2018, 16
DOI: 10.1186/s12964-018-0277-3

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

Heather S Comstra, Jacob McArthy, Samantha Rudin-Rush, Cortnie Hartwig, Avanti Gokhale, Stephanie A Zlatic, Jessica B Blackburn, Erica Werner, Michael Petris, Priya D’Souza, Parinya Panuwet, Dana Boyd Barr, Vladimir Lupashin, Alysia Vrailas-Mortimer and Victor Faundez

eLife, 2017, 6
DOI: 10.7554/eLife.24722

Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells

Mia C. Akerfeldt, Carmen M.-N. Tran, Clara Shen, Trevor W. Hambley and Elizabeth J. New

J Biol Inorg Chem, 2017, 22, 765
DOI: 10.1007/s00775-017-1467-y

Antioxidant Activity Evaluation of Dietary Flavonoid Hyperoside Using Saccharomyces Cerevisiae as a Model

Yuting Gao, Lianying Fang, Xiangxing Wang, Ruoni Lan, Meiyan Wang, Gang Du, Wenqiang Guan, Jianfu Liu, Margaret Brennan, Hongxing Guo, Charles Brennan and Hui Zhao

Molecules, 2019, 24, 788
DOI: 10.3390/molecules24040788

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

Jiabei Zhou, Yu Kang, Lu Chen, Hua Wang, Junqing Liu, Su Zeng and Lushan Yu

Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.00343

Integrative pan-cancer analysis of cuproplasia-associated genes for the genomic and clinical characterization of 33 tumors

Xinyu Li, Weining Ma, Hui Liu, Deming Wang, Lixin Su and Xitao Yang

Chinese Medical Journal, 2023, 136, 2621
DOI: 10.1097/CM9.0000000000002343

Metallomics: An Essential Tool for the Study of Potential Antiparasitic Metallodrugs

Ignacio Machado and Dinorah Gambino

ACS Omega, 2024, 9, 15744
DOI: 10.1021/acsomega.3c10200

RXRα-enriched cancer stem cell-like properties triggered by CDDP in head and neck squamous cell carcinoma (HNSCC)

Pan Jiang, Chaoqi Xu, Ming Zhou, Huaqun Zhou, Weida Dong, Xiaoyue Wu, Aochang Chen and Qing Feng

Carcinogenesis, 2018, 39, 252
DOI: 10.1093/carcin/bgx138

Copper transporter Ctr1 contributes to enhancement of the sensitivity of cisplatin in esophageal squamous cell carcinoma

Xin Wang, Qianqian Lou, Tianli Fan, Qing Zhang, Xiangxiang Yang, Hongtao Liu and Ruitai Fan

Translational Oncology, 2023, 29, 101626
DOI: 10.1016/j.tranon.2023.101626

Mass spectrometric quantification of the binding ratio of metal‐based anticancer complexes with protein thiols

Yumiao Han, Wei Guo, Wei Zheng, Qun Luo, Kui Wu, Yao Zhao and Fuyi Wang

Rapid Comm Mass Spectrometry, 2019, 33, 951
DOI: 10.1002/rcm.8423

Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

Yu-Hsuan Lai, Chin Kuo, Macus Tien Kuo and Helen H. W. Chen

IJMS, 2018, 19, 1486
DOI: 10.3390/ijms19051486

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson

Drug Metabolism and Disposition, 2018, 46, 1776
DOI: 10.1124/dmd.118.082842

Analyzing the whole-transcriptome profiles of ncRNAs and predicting the competing endogenous RNA networks in cervical cancer cell lines with cisplatin resistance

Huimin Lv, Shanshan Jin, Binbin Zou, Yuxiang Liang, Jun Xie and Suhui Wu

Cancer Cell Int, 2021, 21
DOI: 10.1186/s12935-021-02239-6

Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage

Silvano Junior Santini, Giovanni Tarantino, Antonella Iezzi, Anna Alisi and Clara Balsano

Nutr Metab (Lond), 2022, 19
DOI: 10.1186/s12986-022-00641-z

Platinum(IV) antitumor complexes and their nano-drug delivery

Chunyan Jia, Glen B. Deacon, Yingjie Zhang and Chuanzhu Gao

Coordination Chemistry Reviews, 2021, 429, 213640
DOI: 10.1016/j.ccr.2020.213640

Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye

Sumayah Mohammed Asiri, Aviva Levina, Elizabeth J. New and Peter A. Lay

J Biol Inorg Chem, 2022, 28, 43
DOI: 10.1007/s00775-022-01978-9

Dual-mode imaging of copper transporter 1 in HepG2 cells by hyphenating confocal laser scanning microscopy with laser ablation ICPMS

Qi-Xuan Sun, Xing Wei, Shang-Qing Zhang, Ming-Li Chen, Ting Yang, Yong-Liang Yu and Jian-Hua Wang

Anal Bioanal Chem, 2021, 413, 1353
DOI: 10.1007/s00216-020-03097-3