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Aggregation-induced emission spectra of triphenylamine salicylaldehyde derivatives via excited-state intramolecular proton transfer revealed by molecular spectral and dynamics simulations

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When AIE meets enzymes

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Facile synthesis of a class of aminochromene–aniliniumion conjugated far-red to near-infrared fluorescent dyes for bioimaging

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A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission

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Human carboxylesterases and fluorescent probes to image their activity in live cells

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A mechanistic study of AIE processes of TPE luminogens: intramolecular rotation vs. configurational isomerization

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Excited-state intramolecular proton-transfer (ESIPT)-inspired solid state emitters

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A fluorescent light-up platform with “AIE + ESIPT” characteristics for multi-target detection both in solution and on paper strip

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Innovative strategies for enhanced tumor photodynamic therapy

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Monitoring layer-by-layer self-assembly process of natural polyelectrolytes by fluorescent bioconjugate with aggregation-induced emission characteristic

Jingwei Jia, Zhengke Wang, Wentao Lu, Ling Yang, Qingwen Wu, Wei Qin, Qiaoling Hu and Ben Zhong Tang

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Aggregation-induced emission: fundamental understanding and future developments

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Twisted Schiff-base macrocycle showing excited-state intramolecular proton-transfer (ESIPT): assembly and sensing properties

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Origin of green photoluminescence in four-ring bent-core molecules with ESIPT, selective sensing of zinc ions by turn-on emission and their liquid crystal properties

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Photochem Photobiol Sci, 2018, 17, 1386
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An amphiphilic squarylium indocyanine dye for long-term tracking of lysosomes

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Fluorescence turn-on detection of cysteine over homocysteine and glutathione based on “ESIPT” and “AIE”

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Anal. Methods, 2015, 7, 5028
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An AIE and ESIPT based kinetically resolved fluorescent probe for biothiols

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J. Mater. Chem. C, 2016, 4, 2909
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‘AIE + ESIPT’ assisted photorelease: fluorescent organic nanoparticles for dual anticancer drug delivery with real-time monitoring ability

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Chem. Commun., 2018, 54, 168
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Theoretical study on the sensing mechanism of chalcone-based fluorescence probe for detecting hydrogen sulfide and biothiols

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Multicolor monitoring of cellular organelles by single wavelength excitation to visualize the mitophagy process

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Chem. Sci., 2018, 9, 2756
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Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms

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Significant emission enhancement of a bola-amphiphile with salicylaldehyde azine moiety induced by the formation of [2]pseudorotaxane with γ-cyclodextrin

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Synthesis and optical properties of aggregation-induced emission (AIE) molecules based on the ESIPT mechanism as pH- and Zn2+-responsive fluorescent sensors

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A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging

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A novel fluorescent probe based on ESIPT and AIE processes for the detection of hydrogen peroxide and glucose and its application in nasopharyngeal carcinoma imaging

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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging

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A highly selective fluorescent nanoprobe based on AIE and ESIPT for imaging hydrogen sulfide in live cells and zebrafish

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A multi-modal probe for trace water and simultaneously monitoring lipid droplets and lysosomes

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A fluorescent light-up probe based on AIE and ESIPT processes for β-galactosidase activity detection and visualization in living cells

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Self-polymerization of dopamine and polyethyleneimine: novel fluorescent organic nanoprobes for biological imaging applications

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An enzyme-triggered turn-on fluorescent probe based on carboxylate-induced detachment of a fluorescence quencher

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A light-up endoplasmic reticulum probe based on a rational design of red-emissive fluorogens with aggregation-induced emission

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A reaction-based fluorescence probe for selective detection of formaldehyde in food samples and its imaging application in living cells

Jieru Miao, Qiang Zhang, Zhuang Liu and Yan Lu

Org. Biomol. Chem., 2025, 23, 7331
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Mechanistic insights into the design of fluorogenic molecules for wash-free biological applications

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Polymerization-induced emission (PIE) of multifunctional polyamides synthesized by Ugi polymerization and targeted imaging of lysosomes

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A sensitive and rapid “off–on” fluorescent probe for the detection of esterase and its application in evaluating cell status and discrimination of living cells and dead cells

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The photochromism, light harvesting and self-assembly activity of a multi-function Schiff-base compound based on the AIE effect

Jie Chai, Yanbo Wu, Binsheng Yang and Bin Liu

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Tetrazine as a general phototrigger to turn on fluorophores

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A ratiometric fluorescent system for carboxylesterase detection with AIE dots as FRET donors

Yinglong Wu, Shuailing Huang, Fang Zeng, Jun Wang, Changmin Yu, Jing Huang, Huiting Xie and Shuizhu Wu

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Specific light-up bioprobes based on AIEgen conjugates

Jing Liang, Ben Zhong Tang and Bin Liu

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Charge control of fluorescent probes to selectively target the cell membrane or mitochondria: theoretical prediction and experimental validation

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Polymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives

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Nanoscale, 2015, 7, 11486
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Organelle-specific bioprobes based on fluorogens with aggregation-induced emission (AIE) characteristics

Fang Hu and Bin Liu

Org. Biomol. Chem., 2016, 14, 9931
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A novel fluorophore based on the coupling of AIE and ESIPT mechanisms and its application in biothiol imaging

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Synthesis, screening and sensing applications of a novel fluorescent probe based on C-glycosides

Tao Zhang, Tianyi Wang and Zhijie Fang

RSC Adv., 2016, 6, 18357
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Easily fixed simple small ESIPT molecule with aggregation induced emission for fast and photostable “turn-on” bioimaging

Zhenzhen Tu, Min Liu, Yan Qian, Guoqiang Yang, Minmin Cai, Lianhui Wang and Wei Huang

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Halides tuning the subcellular-targeting in two-photon emissive complexes via different uptake mechanisms

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Biscylometalated iridium(iii) complexes target mitochondria or lysosomes by regulating the lipophilicity of the main ligands

Kangqiang Qiu, Yukang Liu, Huaiyi Huang, Chaofeng Liu, Hongyi Zhu, Yu Chen, Liangnian Ji and Hui Chao

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An acidic pH independent piperazine–TPE AIEgen as a unique bioprobe for lysosome tracing

Yuanjing Cai, Chen Gui, Kerim Samedov, Huifang Su, Xinggui Gu, Shiwu Li, Wenwen Luo, Herman H. Y. Sung, Jacky W. Y. Lam, Ryan T. K. Kwok, Ian D. Williams, Anjun Qin and Ben Zhong Tang

Chem. Sci., 2017, 8, 7593
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Non-conjugated fluorescent molecular cages of salicylaldehyde-based tri-Schiff bases: AIE, enantiomers, mechanochromism, anion hosts/probes, and cell imaging properties

Xiaohong Zhang, Jun Shi, Guangyu Shen, Fei Gou, Jinghui Cheng, Xiangge Zhou and Haifeng Xiang

Mater. Chem. Front., 2017, 1, 1041
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Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

Adam C. Sedgwick, Luling Wu, Hai-Hao Han, Steven D. Bull, Xiao-Peng He, Tony D. James, Jonathan L. Sessler, Ben Zhong Tang, He Tian and Juyoung Yoon

Chem. Soc. Rev., 2018, 47, 8842
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A dual fluorogenic and 19F NMR probe for the detection of esterase activity

Jie Hu, Kai Cheng, Qiong Wu, Dashuang Ding, Conggang Li and Zhen Li

Mater. Chem. Front., 2018, 2, 1201
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Multiple stimuli-responsive and reversible fluorescence switches based on a diethylamino-functionalized tetraphenylethene

Zhiming Wang, Han Nie, Zhenqiang Yu, Anjun Qin, Zujin Zhao and Ben Zhong Tang

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Biogenic amine sensors using organic π-conjugated materials as active sensing components and their commercialization potential

Michael J. Grant, Kathryn M. Wolfe, Cayley R. Harding and Gregory C. Welch

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Proteasomal and autophagy-mediated degradation of mutp53 proteins through mitochondria-targeting aggregation-induced-emission materials

Meimei Wang, Zhenyu Yang, Yang Song, Pengfei Wei, Nestor Ishiwme, Liansheng Wang, Hao Zhang, Manman Jing, Meng Gao, Longping Wen and Yunjiao Zhang

Acta Biomaterialia, 2022, 150, 402
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From Light to Insight: Harnessing Fluorescent Probes for Intracellular Pathway Visualization

Shouvik Bhuin, Purbali Chakraborty, Perumal Yogeeswari and Manab Chakravarty

ACS Biomater. Sci. Eng., 2025, 11, 6930
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Lysosome-targeting fluorescent probe for monitoring mitochondrial–lysosomal interactions during autophagy

Xin-Ru Hu, Qiao-Wen Lin, Yu-Meng Wang, Hengchang Zhang, Xiaoqiang Yu, Yeyang Xu, Zhiqiang Liu and Kang-Nan Wang

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A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging

Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu and Jianli Hua

Molecules, 2023, 28, 2317
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Schiff bases constructed from 2-hydroxy-4-methoxybenzophenone hydrazone and aromatic aldehydes: Synthesis, characterization, structure-photophysics relationship, HCl and NH3 stimuli-responsive solid fluorescence, selective detection of Cu2+

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Optical Materials, 2025, 168, 117403
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Electronic effect on the optical properties and sensing ability of AIEgens with ESIPT process based on salicylaldehyde azine

Zhiming Wang, Fan Zhou, Jing Wang, Zujin Zhao, Anjun Qin, Zhenqiang Yu and Ben Zhong Tang

Sci. China Chem., 2018, 61, 76
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Aldehyde end-capped terthiophene with aggregation-induced emission characteristics

Jun Cheng, Xiaozhong Liang, Yaxiong Cao, Kunpeng Guo and Wai-Yeung Wong

Tetrahedron, 2015, 71, 5634
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A colorimetric and ratiometric fluorescent probe for mercury (II) in lysosome

Yufeng Zhang, Haiyan Chen, Dan Chen, Di Wu, Zhao Chen, Jing Zhang, Xiaoqiang Chen, ShengHua Liu and Jun Yin

Sensors and Actuators B: Chemical, 2016, 224, 907
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A Lysosome‐Targeting AIEgen for Autophagy Visualization

Chris Wai Tung Leung, Zhiming Wang, Engui Zhao, Yuning Hong, Sijie Chen, Ryan Tsz Kin Kwok, Anakin Chun Sing Leung, Rongsen Wen, Bingshi Li, Jacky Wing Yip Lam and Ben Zhong Tang

Adv Healthcare Materials, 2016, 5, 427
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ZnII Complexes for Bioimaging and Correlated Applications

Xiaohe Tian, Sajid Hussain, Cesare de Pace, Lorena Ruiz‐Pérez and Giuseppe Battaglia

Chemistry An Asian Journal, 2019, 14, 509
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Rapid preparation of branched and degradable AIE-active fluorescent organic nanoparticles via formation of dynamic phenyl borate bond

Zi Long, Meiying Liu, Liucheng Mao, Guangjian Zeng, Qing Wan, Dazhuang Xu, Fengjie Deng, Hongye Huang, Xiaoyong Zhang and Yen Wei

Colloids and Surfaces B: Biointerfaces, 2017, 150, 114
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Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Kai‐Cheng Yan, Adam C. Sedgwick, Yi Zang, Guo‐Rong Chen, Xiao‐Peng He, Jia Li, Juyoung Yoon and Tony D. James

Small Methods, 2019, 3
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Tetraphenylethene derivatives with AIE-ESIPT characteristics: Synthesis, crystal structures, photophysical properties and application for ClO− detection and pH sensing

Siqin Yi, Hongliang Liu, Xue Li, Zhao Chen, Congbin Fan and Shouzhi Pu

Dyes and Pigments, 2023, 219, 111598
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Fine‐Tuning Molecular Structure of Salicylaldehyde Schiff Base for Solid‐State Photochromic Mechanism

Zhiyang Liu, Zhengjian Lian, Guanqun Zhu, Wenjie Zhang, Qi Qi and Hong Yang

Luminescence, 2025, 40
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A specific AIE and ESIPT fluorescent probe for peroxynitrite detection and imaging in living cells

Youming Shen, Mengyue Li, Ming Yang, Youyu Zhang, Haitao Li and Xiangyang Zhang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 222, 117230
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Multifunctional AIEgens for Future Theranostics

Guangxue Feng and Bin Liu

Small, 2016, 12, 6528
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Tetraphenylethene-based polymeric fluorescent probes for 2,4,6-trinitrophenol detection and specific lysosome labelling

Jinya Yao, Zeyan Zhuang, Hongming Yao, Ruijie Shi, Chenyang Chang, Jian Zhou and Zujin Zhao

Dyes and Pigments, 2020, 182, 108588
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Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging

Wen-Jin Wang, Zhuo-Yang Xin, Xuxian Su, Liang Hao, Zijie Qiu, Kang Li, Yumei Luo, Xu-Min Cai, Jianquan Zhang, Parvej Alam, Jing Feng, Shaojuan Wang, Zheng Zhao and Ben Zhong Tang

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A water-soluble lysosome-targetable fluorescent probe for carboxylesterase detection and its application in biological imaging

Fang-Fang Guo, Wei-Na Wu, Xiao-Lei Zhao, Yuan Wang, Yun-Chang Fan, Chuan-Xiang Zhang and Zhi-Hong Xu

Dyes and Pigments, 2022, 199, 110079
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A hydroxyphenylquinazolinone-based fluorescent probe for turn-on detection of cysteine with a large Stokes shift and its application in living cells

Huace Sheng, Yonghong Hu, Yi Zhou, Shimin Fan, Yang Cao, Xinxin Zhao and Wenge Yang

Journal of Photochemistry and Photobiology A: Chemistry, 2018, 364, 750
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Enzyme-Responsive Bioprobes Based on the Mechanism of Aggregation-Induced Emission

Jie Shi, Ya Li, Qianqian Li and Zhen Li

ACS Appl. Mater. Interfaces, 2018, 10, 12278
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A strategy to distinguish cancers from normal cells through lysosomal targeted double site fluorescent probe for lipase and hydrogen sulfide

Pengli Guan, Shuman Shi, Tingshuo Zhang, Jie Chai, Binsheng Yang and Bin Liu

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Biology-Oriented Design Strategies of AIE Theranostic Probes

Duo Mao and Bin Liu

Matter, 2021, 4, 350
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Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Haidong Li, Heejeong Kim, Jingjing Han, Van‐Nghia Nguyen, Xiaojun Peng and Juyoung Yoon

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Fluorescent Sensors Based on Aggregation-Induced Emission: Recent Advances and Perspectives

Meng Gao and Ben Zhong Tang

ACS Sens., 2017, 2, 1382
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Linear thiophene-containing π-conjugated aldehydes with aggregation-induced emission for building solid red luminophors

Kunpeng Guo, Zhixiang Gao, Jun Cheng, Yang Shao, Xiaoqing Lu and Hua Wang

Dyes and Pigments, 2015, 115, 166
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A Strategy to Distinguish Cancers from Normal Cells Through Lysosomal Targeted Double Site Fluorescent Probe for Lipase and Hydrogen Sulfide

Pengli Guan, Shuman Shi, Tingshuo Zhang, Jie Chai, Binsheng Yang and Bin Liu

SSRN Journal, 2021
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A Multifunctional Probe with Aggregation‐Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells

Meng Gao, Qinglian Hu, Guangxue Feng, Nikodem Tomczak, Rongrong Liu, Bengang Xing, Ben Zhong Tang and Bin Liu

Adv Healthcare Materials, 2015, 4, 659
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Fluorescein as a Visible‐Light‐Induced Oxidase Mimic for Signal‐Amplified Colorimetric Assay of Carboxylesterase by an Enzymatic Cascade Reaction

Li Liu, Chaoqun Sun, Juan Yang, Ying Shi, Yijuan Long and Huzhi Zheng

Chemistry A European J, 2018, 24, 6148
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Cell Membrane Tracker Based on Restriction of Intramolecular Rotation

Chunqiu Zhang, Shubin Jin, Keni Yang, Xiangdong Xue, Zhipeng Li, Yonggang Jiang, Wei-Qiang Chen, Luru Dai, Guozhang Zou and Xing-Jie Liang

ACS Appl. Mater. Interfaces, 2014, 6, 8971
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Multiple Hydrogen Bonds Promoted ESIPT and AIE‐active Chiral Salicylaldehyde Hydrazide

Man Wang, Caiqi Cheng, Jintong Song, Jun Wang, Xiangge Zhou, Haifeng Xiang and Jin Liu

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A sensitive tetraphenylethene-based fluorescent probe for Zn 2+ ion involving ESIPT and CHEF processes

Jing Nie, Nan Li, Zhonghai Ni, Yun Zhao and Lifang Zhang

Tetrahedron Letters, 2017, 58, 1980
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Practicable Applications of Aggregation‐Induced Emission with Biomedical Perspective

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Design, synthesis, and evaluation of a carboxylesterase detection probe with therapeutic effects

Xia Lin, Min Liu, Qingyuan Yi, Ying Zhou, Jinchan Su, Binyang Qing, Yaqi Lu, Chunxiao Pu, Weisen Lan, Lianjia Zou and Jianyi Wang

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Specific Fluorescence Probes for Lipid Droplets Based on Simple AIEgens

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ACS Appl. Mater. Interfaces, 2016, 8, 10193
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A photochromic salicylaldehyde hydrazone derivative based on C N isomerization and ESIPT mechanisms and its detection of Al3+ in aqueous solution

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Design, Synthesis, and Evaluation of Probes for Spatially Resolved Imaging of Enantioselective Sulfoxide Reductases

Anna Tokarenko, Vladimír Nosek and Jiří Míšek

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