Issue 3, 2024

An environmentally benign and atom-economical protocol for the regioselective synthesis of isoquinolones from o-alkynylaldehydes

Abstract

An environmentally benign, transition metal- and base-free, iodine-promoted atom-economical protocol for the synthesis of the privileged isoquinolone scaffold via regioselective intramolecular iodoamidation of alkynes under mild conditions has been developed. The present synthetic approach being metal, additive, and solvent-free adheres to the principles of green chemistry, as it tends to minimize waste production. The synthesized product contains an iodo as well as a free –OH group that is readily accessible for subsequent transformation to afford biologically relevant compounds.

Graphical abstract: An environmentally benign and atom-economical protocol for the regioselective synthesis of isoquinolones from o-alkynylaldehydes

Supplementary files

Article information

Article type
Communication
Submitted
25 okt 2023
Accepted
11 dec 2023
First published
19 dec 2023

Green Chem., 2024,26, 1297-1301

An environmentally benign and atom-economical protocol for the regioselective synthesis of isoquinolones from o-alkynylaldehydes

Muskan and A. K. Verma, Green Chem., 2024, 26, 1297 DOI: 10.1039/D3GC04096H

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