A systematic review on electrochemical sensors for the detection of acetaminophen

Abstract

Electrochemical determination of acetaminophen (AP) has made considerable progress over the past few decades. The nanomaterials or enzyme as electrode modifiers greatly improve the performance parameter of AP electrochemical sensors. This review focuses on the development tendency, detection principle and techniques for the electrochemical analysis of AP. Especially, the design and construction of AP electrochemical sensors were discussed from the perspective of non-enzyme materials (such as nanomaterials including precious metals, transition metals and non-metals) and enzyme substances (such as aryl acylamidase, polyphenol oxidase and horseradish peroxidase). Moreover, the influence factors of AP electrochemical sensor and the simultaneous detection of AP and other targets are summarized, and the prospectivity of AP electrochemical sensor is also outlined. This review provides a reference and guidance for the development and application of electrochemical sensor for AP detection.