Issue 20, 2023

Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes

Abstract

1,3-Dipole cycloaddition reaction represents the most straightforward method for the preparation of tetrazoles. However, this approach commonly requires the use of toxic isocyanides at evaluated temperatures, which raises considerable safety and environmental concerns. Herein we demonstrate that our recently developed electrochemical multicomponent reaction (e-MCR) is a green and sustainable solution to the sulfenyltetrazolation of unactivated alkenes with the readily available thiols azidotrimethylsilane, and acetonitrile, which are inaccessible with the existing methods.

Graphical abstract: Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
05 aug 2023
Accepted
11 sep 2023
First published
11 sep 2023

Org. Chem. Front., 2023,10, 5064-5069

Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes

X. Zhu, Y. Yu, Y. Yuan and K. Ye, Org. Chem. Front., 2023, 10, 5064 DOI: 10.1039/D3QO01241G

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