Issue 51, 2022

Enantioselective synthesis of triarylmethanes via organocatalytic transfer hydrogenation of para-quinone methides

Abstract

A new organocatalytic asymmetric method for the synthesis of enantioenriched triarylmethanes is developed. Different from the conventional approaches featuring asymmetric arylation, the present study employs asymmetric reduction via C–H bond formation as the key step. This approach does not require the presence of a heteroaryl ring or the presynthesis of unstable para-quinone methides. Instead, the stable racemic triarylmethanols were used as substrates for the in situ generation of the intermediates with a suitable chiral phosphoric acid catalyst.

Graphical abstract: Enantioselective synthesis of triarylmethanes via organocatalytic transfer hydrogenation of para-quinone methides

Supplementary files

Article information

Article type
Communication
Submitted
07 apr 2022
Accepted
25 mei 2022
First published
25 mei 2022

Chem. Commun., 2022,58, 7128-7131

Enantioselective synthesis of triarylmethanes via organocatalytic transfer hydrogenation of para-quinone methides

Z. Han, Y. Zang, C. Liu, W. Guo, H. Huang and J. Sun, Chem. Commun., 2022, 58, 7128 DOI: 10.1039/D2CC01996E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements