Issue 25, 2021

Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(ii)-catalyzed access to bridged polyoxocarbocyles

Abstract

This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from rhodium carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. Since only rhodium is employed for this purpose, further exploration of the reaction with other transition metals is lacking. A little research in this area surely depicts the need for further exploration of this technique using other transition metals and ylides (sulfur and nitrogen) for the synthesis of oxa-, aza-, and thia-bridged heterocarbocycles. These polyheterocycles will be future drug candidates being structurally analogous to anthecularin, artemisinin, englerin and intracarene. This review presents a future outlook for organic chemists for further exploration of the synthesis of bridged polyheterocarbocycles.

Graphical abstract: Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(ii)-catalyzed access to bridged polyoxocarbocyles

Article information

Article type
Perspective
Submitted
26 apr 2021
Accepted
31 mei 2021
First published
01 jun 2021

New J. Chem., 2021,45, 11018-11029

Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(II)-catalyzed access to bridged polyoxocarbocyles

S. K. Sahu, P. K. Behera, P. Choudhury, M. Sethi, S. Jena and L. Rout, New J. Chem., 2021, 45, 11018 DOI: 10.1039/D1NJ02034J

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