Issue 72, 2024

Photocatalytic decarboxylation of free carboxylic acids and their functionalization

Abstract

Visible light mediated decarboxylative functionalization of carboxylic acids and their derivatives has recently emerged as a novel and powerful toolkit for small molecule activation in diverse carbon–carbon and carbon–hetero bond forming reactions. Naturally abundant highly functionalized bench-stable carboxylic acid analogs have been employed as promising alternatives to non-trivial organometallic reagents for mild and eco-benign synthetic transformation with traceless CO2 by-products. In this highlight article, we focus on the development of various photodecarboxylative functionalization strategies along with intra/inter-molecular cyclization via concerted single electron transfer (SET) or energy transfer (ET) pathways. Moreover, widely explored carboxylic acids are systematically classified here into four categories; i.e., α-keto, aliphatic, α,β-unsaturated, and aromatic analogs for a concise overview to the readership. The association of decarboxylative radical species with coupling partners to construct C–C and C–N/O/S/P/X bonds for each analogous acid has been presented in brief.

Graphical abstract: Photocatalytic decarboxylation of free carboxylic acids and their functionalization

Article information

Article type
Highlight
Submitted
28 jun 2024
Accepted
01 aug 2024
First published
01 aug 2024

Chem. Commun., 2024,60, 9645-9658

Photocatalytic decarboxylation of free carboxylic acids and their functionalization

S. Mondal, S. Mandal, S. Mondal, S. P. Midya and P. Ghosh, Chem. Commun., 2024, 60, 9645 DOI: 10.1039/D4CC03189J

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