Issue 71, 2024

Time-resolved serial femtosecond crystallography for investigating structural dynamics of chemical systems

Abstract

Time-resolved serial femtosecond crystallography (TR-SFX) has emerged as a crucial tool for studying the structural dynamics of proteins. In principle, TR-SFX has the potential to be a powerful tool not only for studying proteins but also for investigating chemical reactions. However, non-protein systems generally face challenges in indexing due to sparse Bragg spots and encounter difficulties in effectively exciting target molecules. Nevertheless, successful TR-SFX studies on chemical systems have been recently reported in a few instances, boding well for the application of TR-SFX to study chemical reactions in the future. In this context, we review the static SFX and TR-SFX studies conducted on chemical systems reported to date and suggest prospects for future research directions.

Graphical abstract: Time-resolved serial femtosecond crystallography for investigating structural dynamics of chemical systems

Article information

Article type
Highlight
Submitted
28 jun 2024
Accepted
29 jul 2024
First published
09 aug 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 9472-9482

Time-resolved serial femtosecond crystallography for investigating structural dynamics of chemical systems

J. Moon, Y. Lee and H. Ihee, Chem. Commun., 2024, 60, 9472 DOI: 10.1039/D4CC03185G

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