Issue 25, 2023

Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

Abstract

The selective functionalization of alkanes has long been recognized as a prominent challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) processes enable the direct generation of reactive alkyl radicals from feedstock alkanes and have been successfully employed in industrial applications such as the methane chlorination process, etc. Nevertheless, challenges in the regulation of radical generation and reaction pathways have created substantial obstacles in the development of diversified alkane functionalizations. In recent years, the application of photoredox catalysis has provided exciting opportunities for alkane C–H functionalization under extremely mild conditions to trigger HAT processes and achieve radical-mediated functionalizations in a more selective manner. Considerable efforts have been devoted to building more efficient and cost-effective photocatalytic systems for sustainable transformations. In this perspective, we highlight the recent development of photocatalytic systems and provide our views on current challenges and future opportunities in this field.

Graphical abstract: Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

Article information

Article type
Perspective
Submitted
04 mei 2023
Accepted
11 mei 2023
First published
22 mei 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 6841-6859

Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations

L. Chang, S. Wang, Q. An, L. Liu, H. Wang, Y. Li, K. Feng and Z. Zuo, Chem. Sci., 2023, 14, 6841 DOI: 10.1039/D3SC01118F

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