Issue 6, 2023

Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

Abstract

Direct C–H functionalisation methodologies represent an opportunity to improve the overall ‘green’ credentials of organic coupling reactions, improving atom economy and reducing overall step count. Despite this, these reactions frequently run under reaction conditions that leave room for improved sustainability. Herein, we describe a recent advance in our ruthenium-catalysed C–H arylation methodology that aims to address some of the environmental impacts associated with this procedure, including solvent choice, reaction temperature, reaction time, and loading of the ruthenium catalyst. We believe that our findings demonstrate a reaction with improved environmental credentials and showcase it on a multi-gram scale within an industrial setting.

Graphical abstract: Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

Supplementary files

Article information

Article type
Paper
Submitted
14 okt 2022
Accepted
23 feb 2023
First published
07 mrt 2023
This article is Open Access
Creative Commons BY license

Green Chem., 2023,25, 2394-2400

Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

M. T. Findlay, A. S. Hogg, J. J. Douglas and I. Larrosa, Green Chem., 2023, 25, 2394 DOI: 10.1039/D2GC03860A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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