Issue 11, 2023

Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Abstract

Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) are direct participants and important biomarkers of oxidative stress. A comprehensive understanding of their changes can help us evaluate disease pathogenesis and progression and facilitate early diagnosis and drug development. In recent years, fluorescent probes have been developed for real-time monitoring of ROS, RNS and RSS levels in vitro and in vivo. In this review, conventional design strategies of fluorescent probes for ROS, RNS, and RSS detection are discussed from three aspects: fluorophores, linkers, and recognition groups. We introduce representative fluorescent probes for ROS, RNS, and RSS detection in cells, physiological/pathological processes (e.g., Inflammation, Drug Induced Organ Injury and Ischemia/Reperfusion Injury etc.), and specific diseases (e.g., neurodegenerative diseases, epilepsy, depression, diabetes and cancer, etc.). We then highlight the achievements, current challenges, and prospects for fluorescent probes in the pathophysiology of oxidative stress-related diseases.

Graphical abstract: Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Article information

Article type
Review Article
Submitted
27 feb 2022
First published
16 mei 2023
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2023,52, 3873-3926

Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Y. Geng, Z. Wang, J. Zhou, M. Zhu, J. Liu and T. D. James, Chem. Soc. Rev., 2023, 52, 3873 DOI: 10.1039/D2CS00172A

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