Issue 70, 2023

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

Abstract

We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.

Graphical abstract: Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

Supplementary files

Article information

Article type
Communication
Submitted
12 mei 2023
Accepted
03 aug 2023
First published
10 aug 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 10504-10507

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

K. L. F. Hilton, H. Tolley, J. L. Ortega-Roldan, G. S. Thompson, J. M. Sutton, C. K. Hind and J. R. Hiscock, Chem. Commun., 2023, 59, 10504 DOI: 10.1039/D3CC02320F

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