Issue 35, 2022

In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

Abstract

Radiation therapy is a representative therapeutic approach for cancer treatment, wherein the development of efficient radiation sensitizers with low side effects is critical. In this study, a novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. Surface plasmon resonance measurements reveal the good affinity and selectivity of the obtained Au MIP-NGs toward the target dysopsonic protein, human serum albumin. The protein recognition capability of the nanogels led to the formation of the albumin-rich protein corona in the plasma. The Au MIP-NGs acquire stealth capability in vivo through protein corona regulation using the intrinsic dysopsonic proteins. The injection of Au MIP-NGs improved the efficiency of the radiation therapy in mouse models of pancreatic cancer. The growth of the pancreatic tumor was inhibited even at low X-ray doses (2 Gy). The novel strategy reported in this study for the synthesis of stealth nanomaterials based on nanomaterial–protein interaction control shows significant potential for application even in other approaches for cancer treatment, diagnostics, and theranostics. This strategy paves a way for the development of a wide range of effective nanomedicines for cancer therapy.

Graphical abstract: In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

Supplementary files

Article information

Article type
Paper
Submitted
07 mrt 2022
Accepted
16 mei 2022
First published
27 mei 2022

J. Mater. Chem. B, 2022,10, 6784-6791

In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

Y. Kitayama, T. Yamada, K. Kiguchi, A. Yoshida, S. Hayashi, H. Akasaka, K. Igarashi, Y. Nishimura, Y. Matsumoto, R. Sasaki, E. Takano, H. Sunayama and T. Takeuchi, J. Mater. Chem. B, 2022, 10, 6784 DOI: 10.1039/D2TB00481J

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