Issue 7, 2022

Functionalised nanopores: chemical and biological modifications

Abstract

Nanopore technology has established itself as a powerful tool for single-molecule studies. By analysing changes in the ion current flowing through a single transmembrane channel, a wealth of molecular information can be elucidated. Early studies utilised nanopore technology for sensing applications, and subsequent developments have diversified its remit. Nanopores can be synthetic, solid-state, or biological in origin, but recent work has seen these boundaries blurred as hybrid functionalised pores emerge. The modification of existing pores and the construction of novel synthetic pores has been an enticing goal for creating systems with tailored properties and functionality. Here, we explore chemically functionalised biological pores and the bio-inspired functionalisation of solid-state pores, highlighting how the convergence of these domains provides enhanced functionality.

Graphical abstract: Functionalised nanopores: chemical and biological modifications

Article information

Article type
Perspective
Submitted
19 okt 2021
Accepted
22 dec 2021
First published
22 dec 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 1869-1882

Functionalised nanopores: chemical and biological modifications

D. F. Cairns-Gibson and S. L. Cockroft, Chem. Sci., 2022, 13, 1869 DOI: 10.1039/D1SC05766A

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