Issue 49, 2022

Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

Abstract

The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle).

Graphical abstract: Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

Supplementary files

Article information

Article type
Communication
Submitted
13 apr 2022
Accepted
20 mei 2022
First published
20 mei 2022

Chem. Commun., 2022,58, 6890-6893

Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate

C. C. Hanna, J. W. C. Maxwell, H. S. Ismanto, A. S. Ashhurst, L. M. Artner, S. Rudrawar, W. J. Britton, S. Yamasaki and R. J. Payne, Chem. Commun., 2022, 58, 6890 DOI: 10.1039/D2CC02100E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements