PhI(OAc)2-mediated intramolecular oxidative C–N coupling and detosylative aromatization: an access to indolo[2,3-b]quinolines

Quan-Bing Wang; Shi Tang; Ying-Jie Wang; Yue Yuan; Tieqiao Chen; Ai-Qun Jia

doi:10.1039/D1RA01894A

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PhI(OAc)₂-mediated intramolecular oxidative C–N coupling and detosylative aromatization: an access to indolo[2,3-b]quinolines†

Quan-Bing Wang,‡^a Shi Tang,‡*^a Ying-Jie Wang,^a Yue Yuan,^a Tieqiao Chen

^a and Ai-Qun Jia

*^a

Author affiliations

* Corresponding authors

^a School of Life and Pharmaceutical Sciences, Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou, China
E-mail: tangshi705@163.com, ajia@hainanu.edu.cn

Abstract

A PIDA mediated intramolecular oxidative C–N coupling and subsequent detosylative aromatization to afford indolo[2,3-b]quinoline derivatives has been developed. This tandem reaction provided an efficient method for the synthesis of valuable indolo[2,3-b]quinoline derivatives.

This article is part of the themed collection: Elegant Synthetic Routes to Indole Derivatives

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Article information

DOI: https://doi.org/10.1039/D1RA01894A
Article type: Paper
Submitted: 10 mrt 2021
Accepted: 20 apr 2021
First published: 10 mei 2021
This article is Open Access

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RSC Adv., 2021,11, 17206-17211

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PhI(OAc)₂-mediated intramolecular oxidative C–N coupling and detosylative aromatization: an access to indolo[2,3-b]quinolines

Q. Wang, S. Tang, Y. Wang, Y. Yuan, T. Chen and A. Jia, RSC Adv., 2021, 11, 17206 DOI: 10.1039/D1RA01894A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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