Alkoxycarbonyl radicals from alkyloxalyl chlorides: photoinduced synthesis of isoquinolinediones under visible light irradiation

Abstract

Alkyloxalyl chlorides, generated from alcohols and oxalyl chlorides, are used as alkoxycarbonyl radicals in the reaction of N-acryloyl benzamides under photocatalysis at room temperature. In this report, we demonstrate that this approach can be compatible with a variety of alcohol-containing pharmaceutically active compounds under visible light irradiation. A variety of isoquinoline-1,3(2H,4H)-diones are prepared in moderate to good yields.