Issue 9, 2021

Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles

Abstract

Fluoro-containing heterocycles are widely applied in agricultural, medicinal, imaging, materials science and other fields due to their unique physical and chemical properties. Thus, development of new and practical methods for efficiently synthesizing these heterocycle skeletons has been a rapidly growing research field in modern synthetic chemistry. In this review, we provide a summary of the established strategies through fluorination and fluoroalkylation of alkenes/alkynes used over the past decade for constructing fluoro-containing heterocycles. In addition, emphasis is also made in this review on the scopes and mechanisms of these reactions and some of the unsolved scientific problems as well as future directions in this field.

Graphical abstract: Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles

Article information

Article type
Review Article
Submitted
03 jan 2021
Accepted
23 feb 2021
First published
23 feb 2021

Org. Chem. Front., 2021,8, 2079-2109

Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles

X. Wang, J. Lei, Y. Liu, Y. Ye, J. Li and K. Sun, Org. Chem. Front., 2021, 8, 2079 DOI: 10.1039/D0QO01629B

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