Issue 11, 2021

Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

Abstract

The synthesis of heterocycles is an emerging area of chemical research considering their high importance in pharmaceuticals, material chemistry, and natural product synthesis. The development of greener methodologies by employing easily available renewable starting materials has been a long thirst for synthetic chemists. Alcohol is an economical and abundantly available greener substrate produced from diverse sustainable resources. The transition metal-catalyzed acceptorless dehydrogenative coupling (ADC) strategy offers the environmentally benign synthesis of numerous N-heterocycles using alcohols, since only water and hydrogen are produced as the eco-friendly by-products. In this review, we have summarized various aspects of homogeneous and heterogeneously catalyzed recent advancements in the synthesis of heterocycles following the ADC approach.

Graphical abstract: Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

Article information

Article type
Review Article
Submitted
16 dec 2020
Accepted
23 feb 2021
First published
23 feb 2021

Org. Chem. Front., 2021,8, 2673-2709

Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

M. Maji, D. Panja, I. Borthakur and S. Kundu, Org. Chem. Front., 2021, 8, 2673 DOI: 10.1039/D0QO01577F

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