Recent advances in [3+2] cycloaddition of allenes with 1,3-carbonyl ylides; Rh(ii)-catalyzed access to bridged polyoxocarbocyles

Abstract

This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from rhodium carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles. Since only rhodium is employed for this purpose, further exploration of the reaction with other transition metals is lacking. A little research in this area surely depicts the need for further exploration of this technique using other transition metals and ylides (sulfur and nitrogen) for the synthesis of oxa-, aza-, and thia-bridged heterocarbocycles. These polyheterocycles will be future drug candidates being structurally analogous to anthecularin, artemisinin, englerin and intracarene. This review presents a future outlook for organic chemists for further exploration of the synthesis of bridged polyheterocarbocycles.