Issue 1, 2021

Quantitative analysis of excipient dominated drug formulations by Raman spectroscopy combined with deep learning

Abstract

Owing to the growing interest in the application of Raman spectroscopy for quantitative purposes in solid pharmaceutical preparations, an article on the identification of compositions in excipient dominated drugs based on Raman spectra is presented. We proposed label-free Raman spectroscopy in conjunction with deep learning (DL) and non-negative least squares (NNLS) as a solution to overcome the drug fast screening bottleneck, which is not only a great challenge to drug administration, but also a major scientific challenge linked to falsified and/or substandard medicines. The result showed that Raman spectroscopy remains a cost effective, rapid, and user-friendly method, which if combined with DL and NNLS leads to fast implantation in the identification of lactose dominated drug (LDD) formulations. Meanwhile, Raman spectroscopy with the peak matching method allows a visual interpretation of the spectral signature (presence or absence of active pharmaceutical ingredients (APIs) and low content APIs).

Graphical abstract: Quantitative analysis of excipient dominated drug formulations by Raman spectroscopy combined with deep learning

Supplementary files

Article information

Article type
Paper
Submitted
06 okt 2020
Accepted
18 nov 2020
First published
11 dec 2020

Anal. Methods, 2021,13, 64-68

Quantitative analysis of excipient dominated drug formulations by Raman spectroscopy combined with deep learning

X. Fu, L. Zhong, Y. Cao, H. Chen and F. Lu, Anal. Methods, 2021, 13, 64 DOI: 10.1039/D0AY01874K

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