Issue 42, 2020

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

Abstract

An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates.

Graphical abstract: Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

Supplementary files

Article information

Article type
Paper
Submitted
13 jun 2020
Accepted
26 jun 2020
First published
02 jul 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 25165-25169

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

W. Miao, P. Ye, M. Bai, Z. Yang, S. Duan, H. Duan and X. Wang, RSC Adv., 2020, 10, 25165 DOI: 10.1039/D0RA05217E

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