Issue 14, 2020

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

Abstract

This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing.

Graphical abstract: Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
07 jan 2020
Accepted
06 feb 2020
First published
25 feb 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 8161-8171

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

S. Leulmi Pichot, S. Bentouati, S. S. Ahmad, M. Sotiropoulos, R. Jena and R. Cowburn, RSC Adv., 2020, 10, 8161 DOI: 10.1039/D0RA00164C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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