Issue 41, 2020

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

Abstract

With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.

Graphical abstract: A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

Supplementary files

Article information

Article type
Communication
Submitted
20 jan 2020
Accepted
31 mrt 2020
First published
03 apr 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 5532-5535

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

C. S. Kounde, M. M. Shchepinova, C. N. Saunders, M. Muelbaier, M. D. Rackham, J. D. Harling and E. W. Tate, Chem. Commun., 2020, 56, 5532 DOI: 10.1039/D0CC00523A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements