Issue 10, 2018

Self-assembled organic nanorods for dual chemo-photodynamic therapies

Abstract

Photodynamic therapy (PDT) and chemotherapy have been extensively developed as effective approaches against cancer. Herein, we constructed organic nanorods by rational co-assembly of photosensitizer, di-iodinated borondipyrromethene (BDP-I2), and chemical anticancer drug, paclitaxel (PTX). The physico- and photochemical properties of the obtained nanorods were carefully investigated. BDP-I2 was selected for its high singlet oxygen (1O2) quantum yields. And the corresponding 1O2 generation ability and photodynamic effect were evaluated both in vitro and in vivo. The accelerated endosomal escape of the nanorods induced by the photodynamic effect enhanced the chemotherapeutic efficacy of PTX. We believe that this synergetic nanomedicine represents a new development for antitumor chemophotodynamic therapy.

Graphical abstract: Self-assembled organic nanorods for dual chemo-photodynamic therapies

Supplementary files

Article information

Article type
Paper
Submitted
04 jan 2018
Accepted
25 jan 2018
First published
01 feb 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 5493-5499

Self-assembled organic nanorods for dual chemo-photodynamic therapies

Y. Li, X. Hu, X. Zheng, Y. Liu, S. Liu, Y. Yue and Z. Xie, RSC Adv., 2018, 8, 5493 DOI: 10.1039/C8RA00067K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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