Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety†
Cory A.
Ocasio, 
a
Iain J.
Day,
a
Graham J.
Tizzard,
b
Simon J.
Coles,
b
Jonathan M.
Elkins
d
and
John
Spencer
*a
a
Iain J.
Day,
a
Graham J.
Tizzard,
b
Simon J.
Coles,
b
Jonathan M.
Elkins
d
and
John
Spencer
*a
Abstract
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.
- This article is part of the themed collection: SBQ-RSC: Celebrating UK-Brazil collaborations
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