Issue 71, 2016

Palladium-catalyzed Si–C bond-forming silylation of aryl iodides with hydrosilanes: an enhanced enantioselective synthesis of silicon-stereogenic silanes by desymmetrization

Abstract

An enantioselective Pd-catalyzed silicon–carbon bond-forming silylation reaction of aryl iodides with hydrosilanes for the synthesis of silicon-stereogenic silanes has been developed, in which a systematic optimization of a TADDOL-derived monodentate phosphoramidite ligand set resulted in the identification of a new TADDOL-derived phosphoramidite ligand that accesses chiral silanes with moderate to good yield and enantioselectivity under mild conditions.

Graphical abstract: Palladium-catalyzed Si–C bond-forming silylation of aryl iodides with hydrosilanes: an enhanced enantioselective synthesis of silicon-stereogenic silanes by desymmetrization

Supplementary files

Article information

Article type
Communication
Submitted
18 mei 2016
Accepted
08 jul 2016
First published
11 jul 2016

RSC Adv., 2016,6, 67113-67117

Palladium-catalyzed Si–C bond-forming silylation of aryl iodides with hydrosilanes: an enhanced enantioselective synthesis of silicon-stereogenic silanes by desymmetrization

L. Chen, J. Huang, Z. Xu, Z. Zheng, K. Yang, Y. Cui, J. Cao and L. Xu, RSC Adv., 2016, 6, 67113 DOI: 10.1039/C6RA12873D

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