Issue 69, 2016

Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Abstract

A highly efficient, iron nitrate/TEMPO-catalyzed approach for the synthesis of quinazolinones has been achieved via a one-pot, tandem aerobic oxidative cyclization of primary alcohols with 2-aminobenzamides. This practical reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields with air as the terminal green oxidant. Thus, the present synthetic protocol provides an efficient and concise strategy for the synthesis of quinazolinones.

Graphical abstract: Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Supplementary files

Article information

Article type
Paper
Submitted
10 mei 2016
Accepted
30 jun 2016
First published
04 jul 2016

RSC Adv., 2016,6, 65196-65204

Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Y. Hu, L. Chen and B. Li, RSC Adv., 2016, 6, 65196 DOI: 10.1039/C6RA12164K

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