Issue 65, 2016

Nanomaterial mediated optogenetics: opportunities and challenges

Abstract

Optogenetics is a promising neuronal modulation strategy in neuroscience, which enables real-time neuromodulation in free-moving animals with high spatiotemporal control. However, it still suffers from several disadvantages, including low penetration of excitation light and the invasiveness of the insertion of the light delivery system. The incorporation of nanomaterials with different properties into optogenetics may bring new opportunities to solve the problems encountered in optogenetics, from the delivery/expression of the optogene to the stimulation/inhibition and follow-up sensing of neural activity. The challenges of nanomaterial-mediated optogenetics are also discussed. This review elaborates on the feasibility of incorporating nanomaterials into optogenetics and analyzes the benefits of nanomaterial-mediated optogenetics.

Graphical abstract: Nanomaterial mediated optogenetics: opportunities and challenges

Article information

Article type
Review Article
Submitted
01 mei 2016
Accepted
11 jun 2016
First published
13 jun 2016
This article is Open Access
Creative Commons BY license

RSC Adv., 2016,6, 60896-60906

Nanomaterial mediated optogenetics: opportunities and challenges

K. Huang, Q. Dou and X. J. Loh, RSC Adv., 2016, 6, 60896 DOI: 10.1039/C6RA11289G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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