Issue 9, 2016

Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

Abstract

Cocrystallisation with a series of related compounds allows for the exploration of trends and limitations set by structural differences between these compounds. In this work, we investigate how the length of a dicarboxylic acid influences the outcome of cocrystallisation with isoniazid. We have performed a systematic study on the mechanochemical, thermal and solvent vapour-assisted cocrystallisation of aliphatic dicarboxylic acids (C3–C10) with isoniazid. Our results demonstrate that the rate of mechanochemical and vapour-assisted cocrystallisation depends on the acid chain length and shows alternation between odd- and even-chain acids. The results of thermal cocrystallisation showed that the eutectic melting temperatures of isoniazid–dicarboxylic acid mixtures follow the same trend as the melting points of dicarboxylic acids.

Graphical abstract: Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

Supplementary files

Article information

Article type
Paper
Submitted
05 sep 2015
Accepted
27 jan 2016
First published
28 jan 2016

CrystEngComm, 2016,18, 1625-1635

Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

I. Sarceviča, A. Kons and L. Orola, CrystEngComm, 2016, 18, 1625 DOI: 10.1039/C5CE01774B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements