Issue 6, 2015

Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

Abstract

A convenient and efficient synthetic method for the construction of morpholine and piperazine derivatives in moderate to good yields was established. The reaction proceeds smoothly with 1.0 mol% gold catalyst loading. A plausible mechanism involving the cascade cyclization and isomerizations to produce the six-membered ring was proposed and supported by deuterium labeling experiments.

Graphical abstract: Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

Supplementary files

Article information

Article type
Research Article
Submitted
16 feb 2015
Accepted
10 apr 2015
First published
20 apr 2015

Org. Chem. Front., 2015,2, 721-725

Author version available

Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

L. Yao, Y. Wang and K. Huang, Org. Chem. Front., 2015, 2, 721 DOI: 10.1039/C5QO00060B

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