Issue 25, 2015

Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology

Abstract

We describe a modular culture platform that enables spatiotemporal control of the morphology of 2D neural tissues derived from human pluripotent stem cells (hPSCs) by simply adding clickable peptides to the media. It should be widely applicable for elucidating how spatiotemporal changes in morphology and substrate biochemistry regulate tissue morphogenesis.

Graphical abstract: Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology

Supplementary files

Article information

Article type
Communication
Submitted
31 okt 2014
Accepted
05 feb 2015
First published
05 feb 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 5238-5241

Author version available

Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology

G. T. Knight, J. Sha and R. S. Ashton, Chem. Commun., 2015, 51, 5238 DOI: 10.1039/C4CC08665A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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