Issue 25, 2015

A modular DNA origami-based enzyme cascade nanoreactor

Abstract

In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions.

Graphical abstract: A modular DNA origami-based enzyme cascade nanoreactor

Supplementary files

Article information

Article type
Communication
Submitted
27 okt 2014
Accepted
11 jan 2015
First published
12 jan 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 5351-5354

Author version available

A modular DNA origami-based enzyme cascade nanoreactor

V. Linko, M. Eerikäinen and M. A. Kostiainen, Chem. Commun., 2015, 51, 5351 DOI: 10.1039/C4CC08472A

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