Issue 10, 2014
From the journal:

Organic Chemistry Frontiers

Acenaphthoimidazolium chloride-enabled nickel-catalyzed amination of bulky aryl tosylates†‡

Jian Jiang,a   Haibo Zhu,a   Yajing Shena  and  Tao Tu*a  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China
E-mail: taotu@fudan.edu.cn

Abstract

A robust catalyst derived from NiCl2·(DME) and acenaphthoimidazolium chloride exhibited high activity towards the challenging amination of bulky and heterocyclic aryl tosylates with secondary amines under mild reaction conditions at 2 mol% catalyst loading within 3 hours. Further, a wide range of primary amines were also successfully mono-aminated by our newly developed protocol.

Graphical abstract: Acenaphthoimidazolium chloride-enabled nickel-catalyzed amination of bulky aryl tosylates

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Article information

DOI
https://doi.org/10.1039/C4QO00233D
Article type
Research Article
Submitted
22 aug 2014
Accepted
14 sep 2014
First published
15 sep 2014

Org. Chem. Front., 2014,1, 1172-1175

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Acenaphthoimidazolium chloride-enabled nickel-catalyzed amination of bulky aryl tosylates

J. Jiang, H. Zhu, Y. Shen and T. Tu, Org. Chem. Front., 2014, 1, 1172 DOI: 10.1039/C4QO00233D

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