Issue 7, 2014
From the journal:

Organic Chemistry Frontiers

Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature†

Xue-Liang Jiang,a   Zeng-Hao Chen,a   Xiu-Hua Xu*a  and  Feng-Ling Qing*ab  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: xuxiuhua@mail.sioc.ac.cn, flq@mail.sioc.ac.cn

b College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China

Abstract

A convenient copper-mediated direct difluoromethylation of electron-deficient aryl iodides, as well as heteroaryl and β-styryl iodides, using TMSCF2H has been developed. This one-step protocol proceeded at room temperature, affording various difluoromethylated products in moderate to excellent yields.

Graphical abstract: Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

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Article information

DOI
https://doi.org/10.1039/C4QO00153B
Article type
Research Article
Submitted
22 mei 2014
Accepted
18 jun 2014
First published
20 jun 2014

Org. Chem. Front., 2014,1, 774-776

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Copper-mediated difluoromethylation of electron-poor aryl iodides at room temperature

X. Jiang, Z. Chen, X. Xu and F. Qing, Org. Chem. Front., 2014, 1, 774 DOI: 10.1039/C4QO00153B

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