Issue 29, 2023

Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy

Abstract

Nanozyme-based tumour catalytic therapy has attracted widespread attention in recent years, but the therapeutic efficacy is limited due to the trapping of hydroxyl radicals (˙OH) by endogenous glutathione (GSH) in the tumour microenvironment (TME). Zr/Ce-MOFs/DOX/MnO2 is constructed in this work to serve as a new kind of nanozyme for combination chemotherapy and catalytic treatment. Zr/Ce-MOFs can produce ˙OH in a mimic TME, and the MnO2 on the surface could deplete the GSH, further promoting the ˙OH generation. The pH/GSH dual stimulation accelerates the release of anticancer drug doxorubicin (DOX) in tumour tissue for enhanced tumour chemotherapy. Moreover, Mn2+ produced by the reaction of Zr/Ce-MOFs/DOX/MnO2 and GSH can be used as the contrast agent for T1-MRI. The potential antitumour effect of Zr/Ce-MOFs/DOX/MnO2 is demonstrated by in vitro and in vivo cancer treatment tests. This work thus provides a new nanozyme-based platform for enhanced combination chemotherapy and catalytic treatment for tumours.

Graphical abstract: Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy

  • This article is part of the themed collection: Nanozymes

Supplementary files

Article information

Article type
Paper
Submitted
03 mei 2023
Accepted
09 jun 2023
First published
12 jun 2023

J. Mater. Chem. B, 2023,11, 6889-6895

Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy

Q. Song, B. Chi, H. Gao, J. Wang, M. Wu, Y. Xu, Y. Wang, Z. Xu, L. Li, J. Wang and R. Zhang, J. Mater. Chem. B, 2023, 11, 6889 DOI: 10.1039/D3TB01002C

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