Issue 22, 2023

Radical cascade cyclization of 1,n-enynes under photo/electrochemical conditions

Abstract

During the past decade, photo- and electrochemical reactions proceeding via single-electron-transfer (SET) triggered radical pathways have emerged as an indispensable strategy for the efficient formation of chemical bonds. Especially, radical cyclization reactions of 1,n-enynes are widely explored to the synthesis of valuable carbo- and heterocycles, which are ubiquitous in bioactive compounds thus highlighting their relevance. Notably, exceedingly mild conditions usually associated with this kind of chemical transformation enable the modification of multi-functional substrates yielding complex molecular scaffolds. This minireview highlights recent progress in radical cascade cyclizations of 1,n-enynes (n = 5, 6 and 7) under photo/electrochemical conditions until September 2023. We classified the content of the review according to the type of substrates or products in order to offer a better overview and understanding to the readership, hoping this work will exhibit the breath and power of emerging photo- and electrochemical methods in radical chemistry.

Graphical abstract: Radical cascade cyclization of 1,n-enynes under photo/electrochemical conditions

Article information

Article type
Review Article
Submitted
12 sep 2023
Accepted
24 sep 2023
First published
25 sep 2023

Org. Chem. Front., 2023,10, 5735-5745

Radical cascade cyclization of 1,n-enynes under photo/electrochemical conditions

Z. Cai, S. Trienes, K. Liu, L. Ackermann and Y. Zhang, Org. Chem. Front., 2023, 10, 5735 DOI: 10.1039/D3QO01482G

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