Issue 19, 2023

Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

Abstract

With a significant prominence in various strain release transformations, the strained cycloalkanols act as ‘n’ carbon synthons in a multitude of diversified reactions. Their ease of formation, along with facile ring scission through the β-C elimination pathway, foresee various reactivities involving scaffold rearrangements, transition-metal and light-driven transformations, homoenolate mediated chemistry, tandem C–H/C–C bond activations, and so on. This review, therefore, highlights the key developments in the ever-expanding sphere of cycloalkanol chemistry, with key emphasis provided to the higher ring analogues. Prominent breakthroughs since their inception to the recent developments on enantioselective, light-mediated, and electrochemical transformations are also elaborated for the various alkanol systems, thus, featuring their paramount significance.

Graphical abstract: Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

Article information

Article type
Review Article
Submitted
14 jul 2023
Accepted
16 aug 2023
First published
16 aug 2023

Org. Chem. Front., 2023,10, 4941-4971

Strained cycloalkanols in C–C bond formation reactions: a boon in disguise!

N. Jha, P. Mishra and M. Kapur, Org. Chem. Front., 2023, 10, 4941 DOI: 10.1039/D3QO01090B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements