Issue 4, 2023

Radical acylation: concepts, synthetic applications and directions

Abstract

Ketones can serve as prevalent structural cores in natural products, pharmaceuticals, and materials science. The synthesis of ketones is one of the most commonly addressed problems in organic chemistry. Radical chemistry has made significant achievements in the last decade, also streamlining the “diversity-oriented” synthesis of functionalized ketones. This review summarizes and comments on progress in the acylation of carbon-centered radical intermediates for ketone synthesis. Reaction scopes, limitations and mechanisms are discussed based on reaction types and catalytic systems. Conclusions and perspectives are also discussed at the end.

Graphical abstract: Radical acylation: concepts, synthetic applications and directions

Article information

Article type
Review Article
Submitted
18 nov 2022
Accepted
09 jan 2023
First published
09 jan 2023

Org. Chem. Front., 2023,10, 1056-1085

Radical acylation: concepts, synthetic applications and directions

Y. Zhang, Y. Zhang, J. Lin, Z. Li and H. Huang, Org. Chem. Front., 2023, 10, 1056 DOI: 10.1039/D2QO01846B

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