Issue 52, 2023

Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

Abstract

A simple yet powerful D–A type-based NIR-II fluorophore (MTF) with mitochondria targeting was constructed. This mitochondrial targeting dye MTF exhibited not only a photothermal effect but also photodynamic performance, and was further fabricated with DSPE-mPEG to generate nanodots for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy (PDT) and photothermal therapy (PTT).

Graphical abstract: Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

Supplementary files

Article information

Article type
Communication
Submitted
16 mei 2023
Accepted
05 jun 2023
First published
06 jun 2023

Chem. Commun., 2023,59, 8127-8130

Mitochondria-targeted fluorophores for in vivo NIR-II imaging-guided PDT/PTT

Q. Ding, L. Mei, Y. Liu, S. Zhou, L. Chen, Y. Liang, M. Li, H. Zhou, C. Yin and J. S. Kim, Chem. Commun., 2023, 59, 8127 DOI: 10.1039/D3CC02380J

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