Issue 15, 2021

Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

Abstract

A photoinitiated perfluoroalkylative coupling of enamides with perfluoroalkyl iodides and a visible-light-induced difluoroacetylation of enamides with ethyl bromodifluoroacetate have been developed, respectively. These transformations allow the efficacious and straightforward incorporation of biologically and physiologically privileged fluoro-containing moieties into synthetically eminent enamide scaffolds with excellent regio- and stereoselectivities under mild and environmentally friendly conditions.

Graphical abstract: Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

Supplementary files

Article information

Article type
Research Article
Submitted
20 apr 2021
Accepted
21 mei 2021
First published
25 mei 2021

Org. Chem. Front., 2021,8, 4086-4094

Photoinitiated stereoselective direct C(sp2)–H perfluoroalkylation and difluoroacetylation of enamides

K. Zhao, J. Guo, T. Guan, Y. Wang, J. Tao, Y. Zhang, Q. Zhang, K. Ni and T. Loh, Org. Chem. Front., 2021, 8, 4086 DOI: 10.1039/D1QO00605C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements