Issue 28, 2020

Total synthesis of tubulysin U and N14-desacetoxytubulysin H

Abstract

A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging thiazole moiety and the employment of stereoselective reductions and a series of high-yield mild reactions to ensure the requisite stereochemistry, reaction scale, and yield and to avoid the vexing epimerization occurring during peptide formation.

Graphical abstract: Total synthesis of tubulysin U and N14-desacetoxytubulysin H

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
29 mei 2020
Accepted
02 jul 2020
First published
03 jul 2020

Org. Biomol. Chem., 2020,18, 5349-5353

Total synthesis of tubulysin U and N14-desacetoxytubulysin H

B. Long, C. Tao, Y. Li, X. Zeng, M. Cao and Z. Wu, Org. Biomol. Chem., 2020, 18, 5349 DOI: 10.1039/D0OB01109F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements