Issue 10, 2020
From the journal:

Organic & Biomolecular Chemistry

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates†

Johnathan C. Maza, ORCID logo a   Alexandra V. Ramsey,a   Meire Mehare,a   Shane W. Krska, ORCID logo b   Craig A. Parish ORCID logo b  and  Matthew B. Francis ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, University of California, Berkeley, California 94720, USA
E-mail: mbfrancis@berkeley.edu

b Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA

c Materials Science Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

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Article information

DOI
https://doi.org/10.1039/D0OB00211A
Article type
Communication
Submitted
31 jan 2020
Accepted
06 feb 2020
First published
06 feb 2020

Org. Biomol. Chem., 2020,18, 1881-1885

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Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

J. C. Maza, A. V. Ramsey, M. Mehare, S. W. Krska, C. A. Parish and M. B. Francis, Org. Biomol. Chem., 2020, 18, 1881 DOI: 10.1039/D0OB00211A

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