Amide-appended α-hydroxytropolones from a previously described library suppressed herpes simplex virus (HSV) replication in cell culture. A targeted follow-up library led to potent analogs against HSV-1 and -2, including acyclovir-resistant mutants.
Selenium deficiency increases pathogenicity of RNA viruses. While dietary selenium supplementation has been practiced clinically, synthetic selenium compounds are under evaluation for their antiviral activity, important classes are discussed in this essay.
An overview of applications of nanoparticles and their combinations with a variety of antiviral drugs.
Microwave-assisted solvent-free synthesis of antiviral furanochalcones using recyclable MgO: a sustainable protocol.
Viruses are capable of causing serious global health problems. The development of interventions against them is of paramount importance. Here we achieve the sought-after virucidal mechanism using poly(styrene sulfonate) coated gold nanoparticles.