Hyperpolarization read-out through rapidly rotating fields in the zero- and low-field regime

Laurynas Dagys and Christian Bengs

Phys. Chem. Chem. Phys., 2022, 24, 8321
DOI: 10.1039/D1CP04653E

State-of-the-art accounts of hyperpolarized 15N-labeled molecular imaging probes for magnetic resonance spectroscopy and imaging

Hyejin Park and Qiu Wang

Chem. Sci., 2022, 13, 7378
DOI: 10.1039/D2SC01264B

Characterisation of the polarisation transfer to fluorinated pyridines in SABRE

Joni Eronen, S. Karl-Mikael Svensson, Nazmul Hossain, Vladimir V. Zhivonitko, Juha Vaara and Anu M. Kantola

Phys. Chem. Chem. Phys., 2025, 27, 13305
DOI: 10.1039/D5CP01418B

MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition

Shiraz Nantogma, Md Raduanul H. Chowdhury, Mohammad S. H. Kabir, Isaiah Adelabu, Sameer M. Joshi, Anna Samoilenko, Henri de Maissin, Andreas B. Schmidt, Panayiotis Nikolaou, Yuri A. Chekmenev, Oleg G. Salnikov, Nikita V. Chukanov, Igor V. Koptyug, Boyd M. Goodson and Eduard Y. Chekmenev

Anal. Chem., 2024, 96, 4171
DOI: 10.1021/acs.analchem.3c05233

Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy

Shiraz Nantogma, Baptiste Joalland, Ken Wilkens and Eduard Y. Chekmenev

Anal. Chem., 2021, 93, 3594
DOI: 10.1021/acs.analchem.0c05129

Bridging the Gap: From Homogeneous to Heterogeneous Parahydrogen‐induced Hyperpolarization and Beyond

Eduard Y. Chekmenev, Boyd M. Goodson, Valerii I. Bukhtiyarov and Igor V. Koptyug

ChemPhysChem, 2021, 22, 710
DOI: 10.1002/cphc.202001031

Subsecond Three-Dimensional Nitrogen-15 Magnetic Resonance Imaging Facilitated by Parahydrogen-Based Hyperpolarization

Alexandra I. Trepakova, Ivan V. Skovpin, Nikita V. Chukanov, Oleg G. Salnikov, Eduard Y. Chekmenev, Andrey N. Pravdivtsev, Jan-Bernd Hövener and Igor V. Koptyug

J. Phys. Chem. Lett., 2022, 13, 10253
DOI: 10.1021/acs.jpclett.2c02705

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields

Oleg G. Salnikov, Nikita V. Chukanov, Alexandra Svyatova, Ivan A. Trofimov, Mohammad S. H. Kabir, Juri G. Gelovani, Kirill V. Kovtunov, Igor V. Koptyug and Eduard Y. Chekmenev

Angewandte Chemie, 2021, 133, 2436
DOI: 10.1002/ange.202011698

Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid**

Laurynas Dagys, Christian Bengs, Gamal A. I. Moustafa and Malcolm H. Levitt

ChemPhysChem, 2022, 23
DOI: 10.1002/cphc.202200274

Nitrogen-15 dynamic nuclear polarization of nicotinamide derivatives in biocompatible solutions

Josh P. Peters, Arne Brahms, Vivian Janicaud, Maria Anikeeva, Eva Peschke, Frowin Ellermann, Arianna Ferrari, Dana Hellmold, Janka Held-Feindt, Na-mi Kim, Johannes Meiser, Konrad Aden, Rainer Herges, Jan-Bernd Hövener and Andrey N. Pravdivtsev

Sci. Adv., 2023, 9
DOI: 10.1126/sciadv.add3643

Heteronuclear Parahydrogen‐Induced Hyperpolarization via Side Arm Hydrogenation

Oleg G. Salnikov, Nikita V. Chukanov, Andrey N. Pravdivtsev, Dudari B. Burueva, Sergey V. Sviyazov, Kolja Them, Jan‐Bernd Hövener and Igor V. Koptyug

ChemPhysChem, 2025, 26
DOI: 10.1002/cphc.202401119

Enhancing 19F Benchtop NMR Spectroscopy by Combining para-Hydrogen Hyperpolarization and Multiplet Refocusing

Ana I. Silva Terra, Matheus Rossetto, Claire L. Dickson, George Peat, Dušan Uhrín and Meghan E. Halse

ACS Meas. Sci. Au, 2023, 3, 73
DOI: 10.1021/acsmeasuresciau.2c00055

Synthesis and 15N NMR Signal Amplification by Reversible Exchange of [15N]Dalfampridine at Microtesla Magnetic Fields

Nikita V. Chukanov, Oleg G. Salnikov, Ivan A. Trofimov, Mohammad S. H. Kabir, Kirill V. Kovtunov, Igor V. Koptyug and Eduard Y. Chekmenev

ChemPhysChem, 2021, 22, 960
DOI: 10.1002/cphc.202100109

Spin Hyperpolarization in Modern Magnetic Resonance

James Eills, Dmitry Budker, Silvia Cavagnero, Eduard Y. Chekmenev, Stuart J. Elliott, Sami Jannin, Anne Lesage, Jörg Matysik, Thomas Meersmann, Thomas Prisner, Jeffrey A. Reimer, Hanming Yang and Igor V. Koptyug

Chem. Rev., 2023, 123, 1417
DOI: 10.1021/acs.chemrev.2c00534

Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K

Benjamin Chapman, Baptiste Joalland, Collier Meersman, Jessica Ettedgui, Rolf E. Swenson, Murali C. Krishna, Panayiotis Nikolaou, Kirill V. Kovtunov, Oleg G. Salnikov, Igor V. Koptyug, Max E. Gemeinhardt, Boyd M. Goodson, Roman V. Shchepin and Eduard Y. Chekmenev

Anal. Chem., 2021, 93, 8476
DOI: 10.1021/acs.analchem.1c00716

LIGHT-SABRE Hyperpolarizes 1-13C-Pyruvate Continuously without Magnetic Field Cycling

Andrey N. Pravdivtsev, Kai Buckenmaier, Nicolas Kempf, Gabriele Stevanato, Klaus Scheffler, Joern Engelmann, Markus Plaumann, Rainer Koerber, Jan-Bernd Hövener and Thomas Theis

J. Phys. Chem. C, 2023, 127, 6744
DOI: 10.1021/acs.jpcc.3c01128

Synthetic Approaches for 15N‐Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields

Nikita V. Chukanov, Roman V. Shchepin, Sameer M. Joshi, Mohammad S. H. Kabir, Oleg G. Salnikov, Alexandra Svyatova, Igor V. Koptyug, Juri G. Gelovani and Eduard Y. Chekmenev

Chemistry A European J, 2021, 27, 9727
DOI: 10.1002/chem.202100212

Development of Dissolution Dynamic Nuclear Polarization of [15N3]Metronidazole: A Clinically Approved Antibiotic

David O. Guarin, Sameer M. Joshi, Anna Samoilenko, Mohammad S. H. Kabir, Erin E. Hardy, Atsush M. Takahashi, Jan H. Ardenkjaer‐Larsen, Eduard Y. Chekmenev and Yi‐Fen Yen

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202219181

Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization

Josh P. Peters, Charbel Assaf, Arne Brahms, Kolja Them, Mirco Gerdsen, Rainer Herges, Jan-Bernd Hövener and Andrey N. Pravdivtsev

Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.adx2316

Magnetic shielding of parahydrogen hyperpolarization experiments for the masses

Baptiste Joalland, Shiraz Nantogma, Md Raduanul H. Chowdhury, Panayiotis Nikolaou and Eduard Y. Chekmenev

Magnetic Reson in Chemistry, 2021, 59, 1180
DOI: 10.1002/mrc.5167

Low-frequency excitation of singlet–triplet transitions. Application to nuclear hyperpolarization

Laurynas Dagys, Christian Bengs and Malcolm H. Levitt

The Journal of Chemical Physics, 2021, 155
DOI: 10.1063/5.0065863

Rapid 13C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH

Isaiah Adelabu, Jessica Ettedgui, Sameer M. Joshi, Shiraz Nantogma, Md Raduanul H. Chowdhury, Stephen McBride, Thomas Theis, Venkata R. Sabbasani, Mushti Chandrasekhar, Deepak Sail, Kazutoshi Yamamoto, Rolf E. Swenson, Murali C. Krishna, Boyd M. Goodson and Eduard Y. Chekmenev

Anal. Chem., 2022, 94, 13422
DOI: 10.1021/acs.analchem.2c02160

Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-13C]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH

Shiraz Nantogma, Shannon L. Eriksson, Isaiah Adelabu, Iuliia Mandzhieva, Austin Browning, Patrick TomHon, Warren S. Warren, Thomas Theis, Boyd M. Goodson and Eduard Y. Chekmenev

J. Phys. Chem. A, 2022, 126, 9114
DOI: 10.1021/acs.jpca.2c07150

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole by Reversible Parahydrogen Exchange in Microtesla Magnetic Fields

Oleg G. Salnikov, Nikita V. Chukanov, Alexandra Svyatova, Ivan A. Trofimov, Mohammad S. H. Kabir, Juri G. Gelovani, Kirill V. Kovtunov, Igor V. Koptyug and Eduard Y. Chekmenev

Angew Chem Int Ed, 2021, 60, 2406
DOI: 10.1002/anie.202011698

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange

Bryce E. Kidd, Max E. Gemeinhardt, Jamil A. Mashni, Jonathan L. Gesiorski, Liana B. Bales, Miranda N. Limbach, Roman V. Shchepin, Kirill V. Kovtunov, Igor V. Koptyug, Eduard Y. Chekmenev and Boyd M. Goodson

Molecules, 2023, 28, 1198
DOI: 10.3390/molecules28031198

Efficient 15N hyperpolarization of [15N3]metronidazole antibiotic via spin-relayed pulsed SABRE-SHEATH

Shiraz Nantogma, Shannon L. Eriksson, Thomas Theis, Warren S. Warren, Boyd M. Goodson and Eduard Y. Chekmenev

Journal of Magnetic Resonance Open, 2025, 24, 100208
DOI: 10.1016/j.jmro.2025.100208

Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin

Thomas B. R. Robertson, Nicolas Gilbert, Oliver B. Sutcliffe and Ryan E. Mewis

ChemPhysChem, 2021, 22, 1059
DOI: 10.1002/cphc.202100165

Order‐Unity 13C Nuclear Polarization of [1‐13C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement

Isaiah Adelabu, Patrick TomHon, Mohammad S. H. Kabir, Shiraz Nantogma, Mustapha Abdulmojeed, Iuliia Mandzhieva, Jessica Ettedgui, Rolf E. Swenson, Murali C. Krishna, Thomas Theis, Boyd M. Goodson and Eduard Y. Chekmenev

ChemPhysChem, 2022, 23
DOI: 10.1002/cphc.202100839

Decoupling of Spin Decoherence Paths near Zero Magnetic Field

Sven Bodenstedt, Denis Moll, Stefan Glöggler, Morgan W. Mitchell and Michael C. D. Tayler

J. Phys. Chem. Lett., 2022, 13, 98
DOI: 10.1021/acs.jpclett.1c03714

Parahydrogen-based NMR signal amplification by reversible exchange (SABRE): Recent advances and applications

Oleg G. Salnikov, Dudari B. Burueva, Ivan V. Skovpin and Igor V. Koptyug

Mendeleev Communications, 2023, 33, 583
DOI: 10.1016/j.mencom.2023.09.001

15N SABRE Hyperpolarization of Metronidazole at Natural Isotope Abundance

Alexey S. Kiryutin, Alexandra V. Yurkovskaya and Konstantin L. Ivanov

ChemPhysChem, 2021, 22, 1470
DOI: 10.1002/cphc.202100315

Development of Dissolution Dynamic Nuclear Polarization of [15N3]Metronidazole: A Clinically Approved Antibiotic

David O. Guarin, Sameer M. Joshi, Anna Samoilenko, Mohammad S. H. Kabir, Erin E. Hardy, Atsush M. Takahashi, Jan H. Ardenkjaer‐Larsen, Eduard Y. Chekmenev and Yi‐Fen Yen

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202219181

Metal-Mediated Catalytic Polarization Transfer from para Hydrogen to 3,5-Dihalogenated Pyridines

Ben. J. Tickner, Marcus Dennington, Benjamin G. Collins, Callum A. Gater, Theo F. N. Tanner, Adrian C. Whitwood, Peter J. Rayner, Daniel P. Watts and Simon B. Duckett

ACS Catal., 2024, 14, 994
DOI: 10.1021/acscatal.3c05378

15N Hyperpolarization of Metronidazole Antibiotic in Aqueous Media Using Phase-Separated Signal Amplification by Reversible Exchange with Parahydrogen

Sergey V. Sviyazov, Dudari B. Burueva, Nikita V. Chukanov, Ivan A. Razumov, Eduard Y. Chekmenev, Oleg G. Salnikov and Igor V. Koptyug

J. Phys. Chem. Lett., 2024, 15, 5382
DOI: 10.1021/acs.jpclett.4c00875

15N SABRE-SHEATH and NMR/DFT Characterization of Amino-Metronidazole, a Metabolic Product of the Antibiotic and Prospective Hypoxia Contrast Agent Metronidazole

Ishani M. Senanayake, Md Shahabuddin Alam, Mohammad S. H. Kabir, Anthony F. Petrilla, Zahid Siraj, Thomas Theis, Eduard Y. Chekmenev and Boyd M. Goodson

J. Phys. Chem. B, 2025, 129, 1662
DOI: 10.1021/acs.jpcb.4c07877

Inherent loss of parahydrogen-induced polarization for systems with magnetically equivalent nuclei in magnetic field cycling experiments

S. V. Babenko, O. G. Salnikov, R. Z. Sagdeev and I. V. Koptyug

The Journal of Chemical Physics, 2025, 162
DOI: 10.1063/5.0245351

15N hyperpolarisation of the antiprotozoal drug ornidazole by Signal Amplification By Reversible Exchange in aqueous medium

Wissam Iali, Gamal A. I. Moustafa, Laurynas Dagys and Soumya S. Roy

Magnetic Reson in Chemistry, 2021, 59, 1199
DOI: 10.1002/mrc.5144

Rapid SABRE Catalyst Scavenging Using Functionalized Silicas

Thomas B. R. Robertson, Leon J. Clarke and Ryan E. Mewis

Molecules, 2022, 27, 332
DOI: 10.3390/molecules27020332

Solvent Effects in Hyperpolarization of 15N Nuclei in [15N3]Metronidazole and [15N3]Nimorazole Antibiotics via SABRE‐SHEATH**

Anna P. Yi, Oleg G. Salnikov, Dudari B. Burueva, Nikita V. Chukanov, Eduard Y. Chekmenev and Igor V. Koptyug

Analysis & Sensing, 2024, 4
DOI: 10.1002/anse.202400045

Nitrogen-15 and Fluorine-19 Relaxation Dynamics and Spin-Relayed SABRE-SHEATH Hyperpolarization of Fluoro-[15N3]metronidazole

Mohammad S. H. Kabir, Sameer M. Joshi, Anna Samoilenko, Isaiah Adelabu, Shiraz Nantogma, Juri G. Gelovani, Boyd M. Goodson and Eduard Y. Chekmenev

J. Phys. Chem. A, 2023, 127, 5018
DOI: 10.1021/acs.jpca.3c02317