Tandem ring-opening and formal [3 + 2] cycloaddition of furo[2,3-d]pyrimidine-2,4-diones

Li Huang, Ying Han, Jing Sun, Qiu Sun and Chao-Guo Yan

Org. Biomol. Chem., 2023, 21, 6028
DOI: 10.1039/D3OB00769C

Efficient construction of spirocyclopentane-1,3-dioxindoles via an annulation reaction of isocyanides and 3-methyleneoxindoles

Li Huang, Wei-Qing Ma, Jing Sun, Ying Han and Chao-Guo Yan

Org. Biomol. Chem., 2025, 23, 3224
DOI: 10.1039/D5OB00206K

Click chemistry in drug development recent trends and application

Nikhil Nikhil, Anchal Guleria, U. S. Mahadeva Rao, Lee Wan Zhen, Suganya Mahadeva Rao, Kalandar Ameer, Venketash Kumar Krishnamoorthy, Thanapakiam Ganeson, Kamini Vijeepallam, M. Bala Sundaram and Vinoth Kumar Selvaraj

RJPT, 2025, 2416
DOI: 10.52711/0974-360X.2025.00345

Pseudo-seven-component double Ugi reaction with 2,2’-(hexane-1,6-diylbis(oxy))dibenzaldehyde for the synthesis of bis- carboxamides

Afagh Banifereydani, Hossein Nasr-Isfahani, Mohammad Bakherad and Afshin Sarvary

Synthetic Communications, 2025, 55, 1491
DOI: 10.1080/00397911.2025.2572083

Alkynyl‐ or Azido‐Functionalized 1,2,3‐Triazoles: Selective MonoCuAAC Promoted by Physical Factors

Maxim A. Topchiy, Alexandra A. Ageshina, Gleb A. Chesnokov, Grigorii K. Sterligov, Sergey A. Rzhevskiy, Pavel S. Gribanov, Sergey N. Osipov, Mikhail S. Nechaev and Andrey F. Asachenko

ChemistrySelect, 2019, 4, 7470
DOI: 10.1002/slct.201902135

Divergent, C–C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates

Wenqing Xu, Lauren E. Brown and John A. Porco

J. Org. Chem., 2021, 86, 16485
DOI: 10.1021/acs.joc.1c01848

Macrocyclic Pseudopeptides Having Proline or Pipecolic Acid Residues. Efficient Synthesis via Ugi‐Click Strategy

Irina V. Kutovaya, Elena A. Zakharova, Olga I. Shmatova and Valentine G. Nenajdenko

Eur J Org Chem, 2019, 2019, 4855
DOI: 10.1002/ejoc.201900780

Intramolecular Cyclization of Azido-Isocyanides Triggered by the Azide Anion: An Experimental and Computational Study

Mateo Alajarin, Guillermo Cutillas-Font, Carmen Lopez-Leonardo, Raul-Angel Orenes, Marta Marin-Luna and Aurelia Pastor

J. Org. Chem., 2023, 88, 8658
DOI: 10.1021/acs.joc.3c00558

Three-Component Reaction for Efficient Synthesis of Functionalized Spiro[cyclopentane-1,3'-indolines]

Weiqing Ma, Ying Han, Jin Sun and Chaoguo Yan

Chinese Journal of Organic Chemistry, 2021, 41, 3180
DOI: 10.6023/cjoc202103034

Multicomponent Click Reaction: An Indispensable Tool for Easy Access of Functionalized 1,2,3‐Triazoles

Mangal S. Yadav, Sanchayita Rajkhowa, Sumit K. Singh, Manoj K. Jaiswal and Vinod K. Tiwari

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202400776

Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles

Zahra Tashrifi, Mohammad Mohammadi Khanaposhtani, Saeed Bahadorikhalili, Bagher Larijani and Mohammad Mahdavi

COS, 2024, 21, 166
DOI: 10.2174/1570179420666230407103320

Ugi Four-Component Reactions Using Alternative Reactants

Seyyed Emad Hooshmand and Wei Zhang

Molecules, 2023, 28, 1642
DOI: 10.3390/molecules28041642

One-pot approach: Tandem consecutive Ugi-4CR/ACM-type reaction towards the synthesis of functionalised quinoline-2(1H)-one scaffolds

Sivan Perumal Murugan, Chih-Yu Wu, Chinpiao Chen and Gene-Hsian Lee

Tetrahedron Letters, 2021, 67, 152889
DOI: 10.1016/j.tetlet.2021.152889

Recent applications of click chemistry in drug discovery

Xiangyi Jiang, Xia Hao, Lanlan Jing, Gaochan Wu, Dongwei Kang, Xinyong Liu and Peng Zhan

Expert Opinion on Drug Discovery, 2019, 14, 779
DOI: 10.1080/17460441.2019.1614910

Synthesis of Macrocyclic Depsipeptides via the Passerini–Click Reaction Strategy

I. V. Kutovaya and V. G. Nenajdenko

Russ J Org Chem, 2020, 56, 559
DOI: 10.1134/S1070428020040016

δ-Keto Aminoacrylonitriles and δ-Keto Aminoenones from 1-Pyrrolines, Cyanoacetylenes, and Acetylenic Ketones

Ludmila A. Oparina, Anastasiya G. Mal’kina, Nikita A. Kolyvanov, Igor A. Ushakov, Ivan V. Saliy, Konstantin A. Apartsin and Boris A. Trofimov

Synthesis, 2022, 54, 2635
DOI: 10.1055/a-1742-2736

Heteroaryl Rings in Peptide Macrocycles

Ivan V. Smolyar, Andrei K. Yudin and Valentine G. Nenajdenko

Chem. Rev., 2019, 119, 10032
DOI: 10.1021/acs.chemrev.8b00789

Multicomponent synthesis and anti-proliferative screening of biaryl triazole-containing cyclophanes

Eduardo Hernández-Vázquez, Yoarhy A. Amador-Sánchez, Marco A. Cruz-Mendoza, María T. Ramírez-Apán and Luis D. Miranda

Bioorganic & Medicinal Chemistry Letters, 2021, 40, 127899
DOI: 10.1016/j.bmcl.2021.127899

Growing Impact of Intramolecular Click Chemistry in Organic Synthesis

Manoj K. Jaiswal and Vinod K Tiwari

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300167

Isocyanide-based consecutive Bargellini/Ugi reactions: an efficient method for the synthesis of pseudo-peptides containing three amide bonds

Hassan Farhid, Mohammad Taghi Nazeri, Ahmad Shaabani, Mahsa Armaghan and Christoph Janiak

Amino Acids, 2021, 53, 1
DOI: 10.1007/s00726-020-02917-1

Progress in the Synthesis of Fused 1,2,3‐Triazoles

Hariom Kumar, Manoj Dhameja, Marziya Rizvi and Preeti Gupta

ChemistrySelect, 2021, 6, 4889
DOI: 10.1002/slct.202100442

Peptidomimetics based on ammonium decasubstituted pillar[5]arenes: Influence of the alpha-amino acid residue nature on cholinesterase inhibition

Anastasia Nazarova, Pavel Padnya, Alexandra Kharlamova, Konstantin Petrov, George Yusupov, Pavel Zelenikhin, Mikhail Bukharov, Bin Hua, Feihe Huang and Ivan Stoikov

Bioorganic Chemistry, 2023, 141, 106927
DOI: 10.1016/j.bioorg.2023.106927

Peptidomimetics based on thiacalixarene with L-tyrosine moieties: Antibacterial activity against methicillin-resistant Staphylococcus aureus and degradation induced by binding to α-chymotrypsin

Olga Terenteva, Olga Mostovaya, Mikhail Bukharov, Timur Mukhametzyanov, Azamat Bikmukhametov, Anna Lyubina, Alexandra Voloshina, Konstantin Petrov, Pavel Padnya and Ivan Stoikov

Bioorganic Chemistry, 2025, 160, 108434
DOI: 10.1016/j.bioorg.2025.108434

Synthesis of 1,5-disubstituted tetrazole-1,2,3 triazoles hybrids via Ugi-azide/CuAAC

Cesia M. Aguilar-Morales, Denisse de Loera, Claudia Contreras-Celedón, Carlos J. Cortés-García and Luis Chacón-García

Synthetic Communications, 2019, 49, 2086
DOI: 10.1080/00397911.2019.1616301

One-Pot Metal-Free Synthesis of New 1,2,3-Triazolobenzodiaze-pinones by a Sequential Ugi 4CR/Alkyne-Azide Cycloaddition Reaction

Yanmei Yan, Hongli Zhang, Min Yuan, Ruijia Qin, Zhenxing Ren and Yingchun He

Chinese Journal of Organic Chemistry, 2025, 45, 3923
DOI: 10.6023/cjoc202502039

Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach

Rahul P, Joice Thomas, Wim Dehaen and Jubi John

Molecules, 2022, 28, 308
DOI: 10.3390/molecules28010308

Indole-Based Macrocyclization by Metal-Catalyzed Approaches

Subba Rao Cheekatla, Debashis Barik, Geethanjali Anand, Rakhi Mol K. M. and Mintu Porel

Organics, 2023, 4, 333
DOI: 10.3390/org4030026